ArticleInternational journal of environmental research and public health2022
Depression and Anxiety Symptoms Are Associated with Mean Platelet Volume in Autoimmune Disorders.
Article in International journal of environmental research and public health, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 7 citations in OpenAlex.
- The Association Between Peripheral Complete Blood Count Parameters and Depressive Symptoms: A Cross-Sectional Study in Eastern Sudan.Journal of clinical medicine · 2026Article
- Commonalities in frailty and psychopathology predict chronotype across severe mental disorders from a comorbidity perspective.Psychological medicine · 2026Article
- Peripheral immune cell markers as predictors of electroconvulsive treatment response.BMC psychiatry · 2026Article
- Article
- The association between major depressive disorder and generalized anxiety disorder with hematological indices in the Rafsanjan youth cohort study.Scientific reports · 2025Article
- Role of Serum Brain-Derived Neurotrophic Factor as a Biomarker of Chronic Pain in Older Adults.European journal of pain (London, England) · 2025Observational
- Significant haematological alterations in clozapine-treated patients: prevalence and clinical correlation.Acta neuropsychiatrica · 2024Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Platelets are increasingly considered a bridge between mental and immunological disorders. However, data relating to platelet parameters in patients with autoimmune disorders are limited. The aim of the present study was to investigate, for the first time, the association of platelet parameters with the symptoms of affective disorders in patients with autoimmune conditions. In this cross-sectional study, we measured the complete blood count (CBC), the Generalized Anxiety Disorder Scale for anxiety (GAD-7), and the Beck Depression Inventory for depression (BDI) in 121 patients with autoimmune disorders. Mean platelet volume (MPV) was positively correlated with both anxiety and depression. Platelet distribution width (PDW) was negatively correlated with anxiety and depression. Before adjustment for covariates, logistic regression analysis revealed a significant association of MPV with depression and anxiety. After adjustment for covariates, only depression was associated with MPV. The area under the ROC curve of MPV for GAD-7 determined anxiety and BDI determined depression was 0.63. Our study showed that among the CBC hematological parameters, the MPV might be a useful biomarker of depression and anxiety in patients with autoimmune disorders. Further investigations of platelet parameters in controlled prospective studies are warranted to confirm our preliminary results.
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