Evidence map›Paper›PMID 36078646›Full record

ArticleInternational journal of environmental research and public health2022

Association between Polymorphism rs1799732 of

Jolanta Chmielowiec, Krzysztof Chmielowiec, Jolanta Masiak, Małgorzata Śmiarowska, Aleksandra Strońska-Pluta, Violetta Dziedziejko, Anna Grzywacz

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of environmental research and public health, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.8field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. OPRM1 Gene Polymorphism in Women with Alcohol Use Disorder.International journal of molecular sciences · 2024
    Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Jolanta ChmielowiecDepartment of Hygiene and Epidemiology, Collegium Medicum, University of Zielona Gora, 28 Zyty St., 65-046 Zielona Gora, Poland.ORCID 0000-0003-3285-5313
Krzysztof ChmielowiecDepartment of Hygiene and Epidemiology, Collegium Medicum, University of Zielona Gora, 28 Zyty St., 65-046 Zielona Gora, Poland.ORCID 0000-0003-4254-5466
Jolanta MasiakSecond Department of Psychiatry and Psychiatric Rehabilitation, Medical University of Lublin, 1 Głuska St., 20-059 Lublin, Poland.
Małgorzata ŚmiarowskaDepartment of Pharmacokinetics and Therapeutic Drug Monitoring, Pomeranian Medical University, 70-111 Szczecin, Poland.
Aleksandra Strońska-PlutaIndependent Laboratory of Health Promotion, Pomeranian Medical University in Szczecin, 11 Chlapowskiego St., 70-204 Szczecin, Poland.ORCID 0000-0001-6564-2141
Violetta DziedziejkoDepartment of Biochemistry and Medical Chemistry, Pomeranian Medical University, 70-111 Szczecin, Poland.ORCID 0000-0003-4809-415X
Anna GrzywaczIndependent Laboratory of Health Promotion, Pomeranian Medical University in Szczecin, 11 Chlapowskiego St., 70-204 Szczecin, Poland.ORCID 0000-0002-2633-520X
Pomeranian Medical University · PLUniversity of Zielona Góra · PLMedical University of Lublin · PL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Compared to other addictive substances, patients with cannabis addiction are significantly outnumbered by those who report dependence on other, more addictive substances. Unfortunately, most cannabis addiction goes untreated, and among those who choose treatment, the requirements are much higher for adolescents and young adults. THE AIM OF THE STUDY: To examine the relationship of cannabinoid dependency in the genetic context-the association between the rs1799732 polymorphism of the

methodsThe study group consisted of 515 male volunteers. Of these, 214 patients were diagnosed with cannabis addiction and 301 were non-addicted. Patients were diagnosed with NEO Five-Factor Personality Inventory (NEO-FFI), and State-Trait Anxiety Inventory (STAI) questionnaires. The interactions between personality traits and polymorphisms in the

resultsCompared to the control group, the case group obtained significantly higher scores on the STAI State, STAI Trait, Neuroticism and Openness scales, as well as lower scores on the Extraversion, Agreeableness, and Conscientiousness scales. There was no statistically significant difference between addicts and the control group in the frequency of genotypes, but there was a statistically significant difference between addicts and the control group in the frequency of the

conclusionsStudying homogeneous subgroups-as in our study-seems reasonable, particularly when combined with genetic determinants and psychological traits. In multigenic and multifactorial entities, such a strategy has a future.

Indexed as

CannabisMarijuana AbusePersonalityReceptors, Dopamine D2AdolescentDopamineHumansMalePersonality InventoryReceptors, DopamineYoung AdultDopamineDRD2 protein, humanReceptors, DopamineReceptors, Dopamine D2addictionDRD2 gene

Identifiers

PMID36078646
PMCPMC9518330
OpenAlexW4294151989

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.