Evidence map›Paper›PMID 36078349›Full record

ArticleInternational journal of environmental research and public health2022

Disposable E-Cigarettes and Associated Health Risks: An Experimental Study.

Hsien-Chang Lin, Anne Buu, Wei-Chung Su

Open access · goldAbstract read
In one paragraph

Article in International journal of environmental research and public health, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 1 pooled it
2.5field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 1 synthesis or guideline pooled it, 23 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Hsien-Chang LinDepartment of Applied Health Science, School of Public Health, Indiana University Bloomington, 1025 E. 7th St., SPH 116, Bloomington, IN 47405, USA.ORCID 0000-0001-9151-2172
Anne BuuDepartment of Health Promotion and Behavioral Sciences, University of Texas Health Science Center, 7000 Fannin St., Houston, TX 77030, USA.
Wei-Chung SuDepartment of Epidemiology, Human Genetics & Environmental Sciences, University of Texas Health Science Center, 1200 Pressler St., Houston, TX 77030, USA.ORCID 0000-0002-7962-4021
The University of Texas Health Science Center at Houston · USIndiana University Bloomington · US

Funding

Southwest Center for Occupational and Environmental HealthT42OH008421 · OH · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI FELKNOR, SARAH A. · 2005 to 2024
$24.1M
Methodology and measurement for examining short-term and long-term effects of e-cigarette and polysubstance useR01DA049154 · NIDA · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI BUU, YUH-PEY ANNE, LIN, HSIEN-CHANG · 2019 to 2022
$2.6M
Development and Application of a Mobile Apparatus for Ultrafine Particle Inhalation Estimation in Urban CommunitiesR21ES031795 · NIEHS · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI HAN, INKYU, SU, WEI-CHUNG · 2020 to 2021
$428k
NIDA NIH HHS R01 DA049154NIEHS NIH HHS R21 ES031795NIOSH CDC HHS T42 OH008421
6 · The paper itself

Abstract

The use of electronic nicotine delivery systems (ENDS), including disposable e-cigarettes, has been prevalent. Existing chemical analyses of ENDS focused on e-liquids rather than aerosols and failed to consider particle sizes and aerosol respiratory deposition fractions, which are key factors for inhalation doses. This study investigated the organic chemical and metal constituents in size-segregated ENDS aerosol and assessed the deposited doses and health risks of these substances. Aerosol chemical analyses were conducted on two popular disposable ENDS products: Puff Bar (Grape) and Air Bar (Watermelon Ice). An ENDS aerosol was generated and delivered into a Micro-Orifice Uniform Deposit Impactor to collect size-segregated aerosol samples, in which organic chemicals and metals were analyzed. Daily and lifetime doses for each chemical were estimated. Cancer and non-cancer risk assessments were conducted based on the deposited doses. We found that e-cigarette aerosol contains certain harmful organic chemicals and metals documented to result in respiratory problems. Estimated respiratory cancer risks corresponding to chromium from both ENDS products and nickel from Air Bar (Watermelon Ice) were substantially above the conventionally acceptable risk. The method, findings, and implications can contribute to the extant literature of ENDS toxicity studies as well as inform tobacco regulation and future large-scale studies.

Indexed as

Electronic Nicotine Delivery SystemsTobacco ProductsAerosolsMetalsAerosolsMetalsaerosol toxicitydisposable e-cigaretteshealth riskparticle size distributionrespiratory deposition

Identifiers

PMID36078349
PMCPMC9518067
OpenAlexW4293531485

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.