Evidence map›Paper›PMID 36078156›Full record

ArticleCells2022

Functional Intercellular Transmission of miHTT via Extracellular Vesicles: An In Vitro Proof-of-Mechanism Study.

Roberto D V S Morais, Marina Sogorb-González, Citlali Bar, Nikki C Timmer, M Leontien Van der Bent, Morgane Wartel, Astrid Vallès

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cells, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 2 pooled it
0.7field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 2 syntheses or guidelines pooled it, 8 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Review
  4. Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Roberto D V S MoraisDepartment of Research and Development, uniQure Biopharma B.V., 1105 BP Amsterdam, The Netherlands.
Marina Sogorb-GonzálezDepartment of Gastroenterology and Hepatology, Leiden University Medical Center, 2333 ZA Leiden, The Netherlands.ORCID 0000-0002-4500-9995
Citlali BarDepartment of Research and Development, uniQure Biopharma B.V., 1105 BP Amsterdam, The Netherlands.
Nikki C TimmerDepartment of Research and Development, uniQure Biopharma B.V., 1105 BP Amsterdam, The Netherlands.
M Leontien Van der BentDepartment of Research and Development, uniQure Biopharma B.V., 1105 BP Amsterdam, The Netherlands.
Morgane WartelDepartment of Research and Development, uniQure Biopharma B.V., 1105 BP Amsterdam, The Netherlands.ORCID 0000-0002-4955-7972
Astrid VallèsDepartment of Research and Development, uniQure Biopharma B.V., 1105 BP Amsterdam, The Netherlands.
UniQure (Netherlands) · NLLeiden University Medical Center · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Huntington's disease (HD) is a fatal neurodegenerative disorder caused by GAG expansion in exon 1 of the huntingtin (

Indexed as

Extracellular VesiclesHuntingtin ProteinHuntington DiseaseMicroRNAsDependovirusGenetic VectorsHumansTissue DistributionAAV5-miHTTHTT protein, humanHuntingtin ProteinMicroRNAsadeno-associated virusexosomesextracellular vesiclesgene therapyHuntington’s diseaseintercellular communicationmiRNA

Identifiers

PMID36078156
PMCPMC9455173
OpenAlexW4294862257

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.