Evidence map›Paper›PMID 36078143›Full record

ArticleCells2022

Evaluation of the Key Advantages between Two Modalities of Boronophenylalanine Administration for Clinical Boron Neutron Capture Therapy Using an Animal Model.

Yu-Chuan Lin, Yi-Jang Lee, Yi-Wei Chen, Shan-Ying Wang, Fong-In Chou

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cells, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.6field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Yu-Chuan LinNuclear Science and Technology Development Center, National Tsing Hua University, Hsinchu City 300044, Taiwan.ORCID 0000-0001-9680-2005
Yi-Jang LeeDepartment of Biomedical Imaging and Radiological Sciences, National Yang Ming Chiao Tung University, Taipei City 112304, Taiwan.
Yi-Wei ChenDepartment of Oncology, Taipei Veterans General Hospital, Taipei City 112201, Taiwan.
Shan-Ying WangDepartment of Biomedical Imaging and Radiological Sciences, National Yang Ming Chiao Tung University, Taipei City 112304, Taiwan.
Fong-In ChouNuclear Science and Technology Development Center, National Tsing Hua University, Hsinchu City 300044, Taiwan.
National Yang Ming Chiao Tung University · TWNational Tsing Hua University · TW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In clinical boron neutron capture therapy (BNCT), boronophenylalanine (BPA) administrations through one-step infusion (OSI) and two-step infusion (TSI) are the most widely used. This study compared the advantages of OSI and TSI using a human oral squamous cell carcinoma-bearing animal model. OSI was administered at a high-dose rate of 20 mg/kg/min for 20 min (total dose: 400 mg/kg) as the first step infusion. TSI was a prolonged infusion at a low-dose rate of 1.67 mg/kg/min for 15, 30, 45, and 60 min (total dose: 25, 50, 75, and 100 mg/kg) following the first step infusion. The sigmoid

Indexed as

Boron Neutron Capture TherapyBrain NeoplasmsCarcinoma, Squamous CellMouth NeoplasmsAnimalsBoronBoron CompoundsDisease Models, AnimalHumansPhenylalanineBoronBoron CompoundsPhenylalanineboron accumulation effectboron concentrationboron neutron capture therapyboronophenylalanineboron ratioone step infusionpharmacodynamictwo step infusion

Identifiers

PMID36078143
PMCPMC9454519
OpenAlexW4294151586

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.