Evidence map›Paper›PMID 36078104›Full record

ArticleCells2022

Sex-Dependent Role of Adipose Tissue HDAC9 in Diet-Induced Obesity and Metabolic Dysfunction.

Brandee Goo, Samah Ahmadieh, Abdalrahman Zarzour, Nicole K H Yiew, David Kim, Hong Shi, Jacob Greenway, Stephen Cave, Jenny Nguyen, Swetha Aribindi and 8 more

Open access · goldAbstract read
In one paragraph

Article in Cells, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.4field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
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  6. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 1 institution in 1 country.

Brandee GooVascular Biology Center, Medical College of Georgia, Augusta University, 1120 15th St., CB3940, Augusta, GA 30912, USA.ORCID 0000-0002-9994-6706
Samah AhmadiehVascular Biology Center, Medical College of Georgia, Augusta University, 1120 15th St., CB3940, Augusta, GA 30912, USA.
Abdalrahman ZarzourVascular Biology Center, Medical College of Georgia, Augusta University, 1120 15th St., CB3940, Augusta, GA 30912, USA.
Nicole K H YiewVascular Biology Center, Medical College of Georgia, Augusta University, 1120 15th St., CB3940, Augusta, GA 30912, USA.
David KimVascular Biology Center, Medical College of Georgia, Augusta University, 1120 15th St., CB3940, Augusta, GA 30912, USA.ORCID 0000-0001-6896-6950
Hong ShiVascular Biology Center, Medical College of Georgia, Augusta University, 1120 15th St., CB3940, Augusta, GA 30912, USA.
Jacob GreenwayVascular Biology Center, Medical College of Georgia, Augusta University, 1120 15th St., CB3940, Augusta, GA 30912, USA.
Stephen CaveVascular Biology Center, Medical College of Georgia, Augusta University, 1120 15th St., CB3940, Augusta, GA 30912, USA.
Jenny NguyenVascular Biology Center, Medical College of Georgia, Augusta University, 1120 15th St., CB3940, Augusta, GA 30912, USA.
Swetha AribindiVascular Biology Center, Medical College of Georgia, Augusta University, 1120 15th St., CB3940, Augusta, GA 30912, USA.
Mark WendolowskiVascular Biology Center, Medical College of Georgia, Augusta University, 1120 15th St., CB3940, Augusta, GA 30912, USA.
Praneet VeerapaneniVascular Biology Center, Medical College of Georgia, Augusta University, 1120 15th St., CB3940, Augusta, GA 30912, USA.
Mourad OgbiVascular Biology Center, Medical College of Georgia, Augusta University, 1120 15th St., CB3940, Augusta, GA 30912, USA.
Weiqin ChenDepartments of Physiology and Regenerative Medicine, Medical College of Georgia, Augusta University, 1120 15th St., CA3126, Augusta, GA 30912, USA.
Yun LeiDepartments of Neuroscience and Regenerative Medicine, Medical College of Georgia, Augusta University, 1120 15th St., CA3008, Augusta, GA 30912, USA.
Xin-Yun LuDepartments of Neuroscience and Regenerative Medicine, Medical College of Georgia, Augusta University, 1120 15th St., CA3008, Augusta, GA 30912, USA.
Ha Won KimVascular Biology Center, Medical College of Georgia, Augusta University, 1120 15th St., CB3940, Augusta, GA 30912, USA.ORCID 0000-0001-6272-4248
Neal L WeintraubVascular Biology Center, Medical College of Georgia, Augusta University, 1120 15th St., CB3940, Augusta, GA 30912, USA.ORCID 0000-0002-5138-3705
Augusta University · US

Funding

The Adipocyte PPARgama/Adiponectin Axis and Alzheimer's DiseaseRF1AG062166 · NIA · AUGUSTA UNIVERSITY · PI LU, XIN-YUN · 2019 to 2019
$3.5M
Neuronal HDAC9, Synaptic Plasticity and Alzheimer's DiseaseR01AG076235 · NIA · AUGUSTA UNIVERSITY · PI Xin-Yun Lu, Neal L Weintraub · 2022 to 2026
$2.8M
Innovative Approaches to Treat Duchenne Muscular Dystrophy Using iPSC-Derived Muscle ProgenitorsR01AR070029 · NIAMS · AUGUSTA UNIVERSITY · PI ASHRAF, MUHAMMAD, TANG, YAO LIANG · 2016 to 2021
$2.6M
Notch1/miR-322 Axis in Stem Cell Mediated Vascular RepairR01HL134354 · NHLBI · AUGUSTA UNIVERSITY · PI ASHRAF, MUHAMMAD, TANG, YAO LIANG · 2016 to 2020
$2.5M
Mechanisms of myeloperoxidase and Nox4 interactions in abdominal aortic aneurysmR01HL142097 · NHLBI · AUGUSTA UNIVERSITY · PI WEINTRAUB, NEAL L · 2018 to 2021
$2.1M
Perivascular adipose tissue and vascular remodelingR01HL112640 · NHLBI · UNIVERSITY OF CINCINNATI · PI WEINTRAUB, NEAL L · 2012 to 2016
$2.1M
Epigenetic regulation of HDAC9 in obesity and atherosclerosisR01HL126949 · NHLBI · AUGUSTA UNIVERSITY · PI WEINTRAUB, NEAL L · 2016 to 2019
$1.8M
HDAC9, Aging and Alzheimer's DiseaseR56AG064895 · NIA · AUGUSTA UNIVERSITY · PI LU, XIN-YUN, WEINTRAUB, NEAL L · 2019 to 2020
$1.5M
Role of Histone Deacetylase 9 (HDAC9) in adipose tissue aging: mitochondrial function, oxidative stress and senescenceF30AG074640 · NIA · AUGUSTA UNIVERSITY · PI GOO, BRANDEE · 2022 to 2024
$158k
NHLBI NIH HHS R01 HL112640NHLBI NIH HHS R01 HL126949NHLBI NIH HHS R01 HL134354NHLBI NIH HHS R01 HL142097NIAMS NIH HHS R01 AR070029NIA NIH HHS F30 AG074640NIA NIH HHS R01 AG076235NIA NIH HHS R56 AG064895NIA NIH HHS RF1 AG062166
6 · The paper itself

Abstract

Obesity is a major risk factor for both metabolic and cardiovascular disease. We reported that, in obese male mice, histone deacetylase 9 (HDAC9) is upregulated in adipose tissues, and global deletion of HDAC9 protected against high fat diet (HFD)-induced obesity and metabolic disease. Here, we investigated the impact of adipocyte-specific

Indexed as

Histone DeacetylasesMetabolic DiseasesObesityAdipose TissueAnimalsDiet, High-FatFemaleHumansMiceMice, ObeseRepressor ProteinsHDAC9 protein, humanHdac9 protein, mouseHistone DeacetylasesRepressor ProteinsHDAC9high fat dietinsulin resistanceobesity

Identifiers

PMID36078104
PMCPMC9454798
OpenAlexW4293776817

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.