Evidence map›Paper›PMID 36078094›Full record

ReviewCells2022

Potential Therapeutic Role of Mesenchymal-Derived Stem Cells as an Alternative Therapy to Combat COVID-19 through Cytokines Storm.

Tarun Kumar Upadhyay, Rashmi Trivedi, Fahad Khan, Pratibha Pandey, Amit Baran Sharangi, Harsh Goel, Mohd Saeed, Moon Nyeo Park, Bonglee Kim

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Cells, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.5field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 3 countries.

Tarun Kumar UpadhyayDepartment of Biotechnology, Parul Institute of Applied Sciences and Animal Cell Culture and Immunobiochemistry Lab, Centre of Research for Development, Parul University, Vadodara 391760, India.ORCID 0000-0002-2551-9779
Rashmi TrivediDepartment of Biotechnology, Parul Institute of Applied Sciences and Animal Cell Culture and Immunobiochemistry Lab, Centre of Research for Development, Parul University, Vadodara 391760, India.
Fahad KhanDepartment of Biotechnology, Noida Institute of Engineering & Technology, Greater Noida 201306, India.ORCID 0000-0003-3449-7978
Pratibha PandeyDepartment of Biotechnology, Noida Institute of Engineering & Technology, Greater Noida 201306, India.ORCID 0000-0001-7029-8517
Amit Baran SharangiDepartment of Plantation, Spices, Medicinal & Aromatic Crops, BCKV-Agricultural University, Mohanpur 741252, India.ORCID 0000-0001-6630-5999
Harsh GoelDepartment of Laboratory Oncology, All India Institute of Medical Sciences, New Delhi 110023, India.ORCID 0000-0003-3904-7343
Mohd SaeedDepartment of Biology, College of Sciences, University of Hail, Hail 34464, Saudi Arabia.ORCID 0000-0003-3443-386X
Moon Nyeo ParkDepartment of Korean Medicine, Kyung Hee University, Seoul 05254, Korea.ORCID 0000-0002-9276-3894
Bonglee KimDepartment of Pathology, College of Korean Medicine, Kyung Hee University, Seoul 02447, Korea.ORCID 0000-0002-8678-156X
Jaypee Institute of Information Technology · INKyung Hee University · KRParul University · INAll India Institute of Medical Sciences · INUniversity of Ha'il · SA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Medical health systems continue to be challenged due to newly emerging COVID-19, and there is an urgent need for alternative approaches for treatment. An increasing number of clinical observations indicate cytokine storms to be associated with COVID-19 severity and also to be a significant cause of death among COVID-19 patients. Cytokine storm involves the extensive proliferative and hyperactive activity of T and macrophage cells and the overproduction of pro-inflammatory cytokines. Stem cells are the type of cell having self-renewal properties and giving rise to differentiated cells. Currently, stem cell therapy is an exciting and promising therapeutic approach that can treat several diseases that were considered incurable in the past. It may be possible to develop novel methods to treat various diseases by identifying stem cells' growth and differentiation factors. Treatment with mesenchymal stem cells (MSCs) in medicine is anticipated to be highly effective. The present review article is organized to put forward the positive arguments and implications in support of mesenchymal stem cell therapy as an alternative therapy to cytokine storms, to combat COVID-19. Using the immunomodulatory potential of the MSCs, it is possible to fight against COVID-19 and counterbalance the cytokine storm.

Indexed as

COVID-19Cytokine Release SyndromeMesenchymal Stem CellsMesenchymal Stem Cell TransplantationCytokinesHumansCytokinesCOVID-19cytokine storminflammationmesenchymal stem cellsstem cell therapy

Identifiers

PMID36078094
PMCPMC9455060
OpenAlexW4293524917

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.