Evidence map›Paper›PMID 36078086›Full record

ArticleCells2022

Targeting Anti-Angiogenic VEGF

Sivaraman Kuppuswamy, Brian H Annex, Vijay C Ganta

Open access · goldAbstract read
In one paragraph

Article in Cells, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.9field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 23 citations in OpenAlex.

  1. Article
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  11. Peripheral arterial disease: A small and large vessel problem.American heart journal plus : cardiology research and practice · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Sivaraman KuppuswamyVascular Biology Center and Department of Medicine, Augusta University, Augusta, GA 30912, USA.
Brian H AnnexVascular Biology Center and Department of Medicine, Augusta University, Augusta, GA 30912, USA.ORCID 0000-0001-6538-8243
Vijay C GantaVascular Biology Center and Department of Medicine, Augusta University, Augusta, GA 30912, USA.ORCID 0000-0002-2967-8320
Augusta University Health · US

Funding

Systems Biology of Angiogenesis in Peripheral Arterial DiseaseR01HL101200 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI POPEL, ALEKSANDER S. · 2010 to 2022
$10.7M
Clinical Phenotyping and Disease Specific Sampling to Identify Non-coding RNAs for Human Therapeutics in PADR01HL150003 · NHLBI · AUGUSTA UNIVERSITY · PI ANNEX, BRIAN H, MCCLUNG, JOSEPH MATTHEW · 2020 to 2023
$3.0M
Precision Medicine for Therapeutic Angiogenesis in Peripheral Arterial Disease: Targeting of the IL21R PathwayR01HL148590 · NHLBI · AUGUSTA UNIVERSITY · PI ANNEX, BRIAN H · 2019 to 2022
$2.9M
The Anti-angiogenic VEGF165b and VEGFR1 Signaling in Peripheral Artery DiseaseR01HL141325 · NHLBI · UNIVERSITY OF VIRGINIA · PI ANNEX, BRIAN H · 2019 to 2022
$2.7M
New Roles for VEGFR1 in AngiogenesisR01GM129074 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI MAC GABHANN, FEILIM C · 2018 to 2021
$2.6M
A Two Amino Acid Switch in the Anti-angiogenic VEGF165b isoform creates a Novel Agent for Therapeutic Angiogenesis in Peripheral Artery DiseaseR01HL146673 · NHLBI · UNIVERSITY OF VIRGINIA · PI GANTA, VIJAY CHAITANYA · 2019 to 2023
$1.9M
NHLBI NIH HHS R01 HL101200NHLBI NIH HHS R01 HL141325NHLBI NIH HHS R01 HL146673NHLBI NIH HHS R01 HL148590NHLBI NIH HHS R01 HL150003NIGMS NIH HHS R01 GM129074
6 · The paper itself

Abstract

Nitric oxide (NO) is the critical regulator of VEGFR2-induced angiogenesis. Neither VEGF-A over-expression nor L-Arginine (NO-precursor) supplementation has been effective in helping patients with Peripheral Artery Disease (PAD) in clinical trials. One incompletely studied reason may be due to the presence of the less characterized anti-angiogenic VEGF-A (VEGF

Indexed as

Peripheral Arterial DiseaseVascular Endothelial Growth Factor AAnimalsIschemiaMiceNeovascularization, PathologicNeovascularization, PhysiologicNitric OxideProtein IsoformsNitric OxideProtein IsoformsVascular Endothelial Growth Factor Aangiogenesisanti-angiogenic VEGF-Adiabetesgrowth factor signalingischemianitric oxide

Identifiers

PMID36078086
PMCPMC9454804
OpenAlexW4293659613

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.