Evidence map›Paper›PMID 36077908›Full record

ArticleAnimals : an open access journal from MDPI2022

Molecular Characterization and Phylogenetic Analysis of a Variant Recombinant Porcine Epidemic Diarrhea Virus Strain in China.

Xiaoliang Hu, Yuexiao Lian, Yucan He, Xiangxiao Liu, Zhige Tian, Yi Dai, Mengyuan Liu, Huayan Fan, Yue Shi, Feng Cong

Open access · goldAbstract read
In one paragraph

Article in Animals : an open access journal from MDPI, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.0field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Xiaoliang HuFaculty of Agriculture, Forestry and Food Engineering, Yibin Key Laboratory of Zoological Diversity and Ecological Conservation, Yibin Animal and Plant Inspection and Quarantine Engineering Technology Research Center, Yibin University, Yibin 644000, China.
Yuexiao LianGuangdong Laboratory Animals Monitoring Institute, Guangdong Provincial Key Laboratory of Laboratory Animals, Guangzhou 510633, China.
Yucan HeFaculty of Agriculture, Forestry and Food Engineering, Yibin Key Laboratory of Zoological Diversity and Ecological Conservation, Yibin Animal and Plant Inspection and Quarantine Engineering Technology Research Center, Yibin University, Yibin 644000, China.
Xiangxiao LiuFaculty of Agriculture, Forestry and Food Engineering, Yibin Key Laboratory of Zoological Diversity and Ecological Conservation, Yibin Animal and Plant Inspection and Quarantine Engineering Technology Research Center, Yibin University, Yibin 644000, China.
Zhige TianFaculty of Agriculture, Forestry and Food Engineering, Yibin Key Laboratory of Zoological Diversity and Ecological Conservation, Yibin Animal and Plant Inspection and Quarantine Engineering Technology Research Center, Yibin University, Yibin 644000, China.
Yi DaiFaculty of Agriculture, Forestry and Food Engineering, Yibin Key Laboratory of Zoological Diversity and Ecological Conservation, Yibin Animal and Plant Inspection and Quarantine Engineering Technology Research Center, Yibin University, Yibin 644000, China.
Mengyuan LiuFaculty of Agriculture, Forestry and Food Engineering, Yibin Key Laboratory of Zoological Diversity and Ecological Conservation, Yibin Animal and Plant Inspection and Quarantine Engineering Technology Research Center, Yibin University, Yibin 644000, China.
Huayan FanFaculty of Agriculture, Forestry and Food Engineering, Yibin Key Laboratory of Zoological Diversity and Ecological Conservation, Yibin Animal and Plant Inspection and Quarantine Engineering Technology Research Center, Yibin University, Yibin 644000, China.
Yue ShiBeijing Senkang Biotech Development Co., Ltd., Beijing 100000, China.
Feng CongGuangdong Laboratory Animals Monitoring Institute, Guangdong Provincial Key Laboratory of Laboratory Animals, Guangzhou 510633, China.
Yibin University · CNGuangdong Laboratory Animals Monitoring Institute · CNBeijing VDJBio (China) · CN

Funding

Feng Cong development projects in key areas of Guangdong ProvinceXiaoliang Hu Doctor Launch Project of Yibin UniversityYuexiao Lian National Key R&D Program of ChinaZhige Tian Doctor Launch Project of Yibin University
6 · The paper itself

Abstract

Since 2010, a variant of porcine epidemic diarrhea virus (PEDV) has re-emerged in several provinces of China, resulting in severe economic losses for the pork industry. Here, we isolated and identified a variant PEDV strain, SC-YB73, in Guangdong Province, China. The pathological observations of jejunum showed atrophy of villi and edema in the lamina propria. The sequence analysis of the viral genome identified a six-nucleotide insertion in the E gene, which has not previously been detected in PEDV strains. Furthermore, 50 nucleotide sites were unique in SC-YB73 compared with 27 other PEDV strains. The phylogenetic analysis based on the complete genome showed that SC-YB73 was clustered in variant subgroup GII-a, which is widely prevalent in the Chinese pig population. The recombination analysis suggested that SC-YB73 originated from the recombination of GDS47, US PEDV prototype-like strains TW/Yunlin550/2018, and COL/Cundinamarca/2014. In the present study, we isolated and genetically characterized a variant PEDV strain, thus providing essential information for the control of PED outbreaks in China.

Indexed as

E geneinsertionpathogenicityporcine epidemic diarrhea virusvariant

Identifiers

PMID36077908
PMCPMC9454955
OpenAlexW4293106258

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.