Evidence map›Paper›PMID 36077763›Full record

ArticleCancers2022

Oncogenic EFNA4 Amplification Promotes Lung Adenocarcinoma Lymph Node Metastasis.

Xiangyu Zhao, Yuxing Chen, Xiaoqin Sun, Zaoke He, Tao Wu, Chenxu Wu, Jing Chen, Jinyu Wang, Kaixuan Diao, Xue-Song Liu

Open access · goldAbstract read
In one paragraph

Article in Cancers, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.0field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. EFNA4-enhanced deubiquitination of SLC7A11 inhibits ferroptosis in hepatocellular carcinoma.Apoptosis : an international journal on programmed cell death · 2025
    Article
  6. Article
  7. Article
  8. Advances in lymphatic metastasis of non-small cell lung cancer.Cell communication and signaling : CCS · 2024
    Review
  9. Article
  10. Article
  11. May EPH/Ephrin Targeting Revolutionize Lung Cancer Treatment?International journal of molecular sciences · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Xiangyu ZhaoSchool of Life Science and Technology, ShanghaiTech University, Shanghai 201203, China.
Yuxing ChenSchool of Life Science and Technology, ShanghaiTech University, Shanghai 201203, China.
Xiaoqin SunSchool of Life Science and Technology, ShanghaiTech University, Shanghai 201203, China.
Zaoke HeSchool of Life Science and Technology, ShanghaiTech University, Shanghai 201203, China.
Tao WuSchool of Life Science and Technology, ShanghaiTech University, Shanghai 201203, China.ORCID 0000-0002-8999-9628
Chenxu WuSchool of Life Science and Technology, ShanghaiTech University, Shanghai 201203, China.
Jing ChenSchool of Life Science and Technology, ShanghaiTech University, Shanghai 201203, China.
Jinyu WangSchool of Life Science and Technology, ShanghaiTech University, Shanghai 201203, China.
Kaixuan DiaoSchool of Life Science and Technology, ShanghaiTech University, Shanghai 201203, China.
Xue-Song LiuSchool of Life Science and Technology, ShanghaiTech University, Shanghai 201203, China.ORCID 0000-0002-7736-0077
ShanghaiTech University · CNChinese Academy of Sciences · CN

Funding

National Natural Science Foundation of China 31771373Shanghai Science and Technology Commission 21ZR1442400ShanghaiTech University liuxs
6 · The paper itself

Abstract

Lymph nodes metastases are common in patients with lung cancer. Additionally, those patients are often at a higher risk for death from lung tumor than those with tumor-free lymph nodes. Somatic DNA alterations are key drivers of cancer, and copy number alterations (CNAs) are major types of DNA alteration that promote lung cancer progression. Here, we performed genome-wide DNA copy number analysis, and identified a novel lung-cancer-metastasis-related gene,

Indexed as

copy number alterationsEFNA4lung cancerlymph node metastasis

Identifiers

PMID36077763
PMCPMC9454565
OpenAlexW4293776777

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.