Evidence map›Paper›PMID 36077746›Full record

ArticleCancers2022

Genomic Landscape Alterations in Primary Tumor and Matched Lymph Node Metastasis in Hormone-Naïve Prostate Cancer Patients.

Giorgio Ivan Russo, Paolo Bonacci, Dalida Bivona, Grete Francesca Privitera, Giuseppe Broggi, Rosario Caltabiano, Jessica Vella, Arturo Lo Giudice, Maria Giovanna Asmundo, Sebastiano Cimino and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancers, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.5field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Comparison ofFrontiers in urology · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 1 institution in 1 country.

Giorgio Ivan RussoUrology Section, Department of Surgery, University of Catania, 95125 Catania, Italy.ORCID 0000-0003-4687-7353
Paolo BonacciDepartment of Biomedical and Biotechnological Sciences (BIOMETEC), University of Catania, 95125 Catania, Italy.ORCID 0000-0002-7305-7433
Dalida BivonaDepartment of Biomedical and Biotechnological Sciences (BIOMETEC), University of Catania, 95125 Catania, Italy.ORCID 0000-0002-2448-0227
Grete Francesca PriviteraDepartment of Biomedical and Biotechnological Sciences (BIOMETEC), University of Catania, 95125 Catania, Italy.ORCID 0000-0003-1807-4780
Giuseppe BroggiDepartment of Medical and Surgical Sciences and Advanced Technologies "G. F. Ingrassia", Anatomic Pathology, University of Catania, 95125 Catania, Italy.ORCID 0000-0003-2576-6523
Rosario CaltabianoDepartment of Medical and Surgical Sciences and Advanced Technologies "G. F. Ingrassia", Anatomic Pathology, University of Catania, 95125 Catania, Italy.ORCID 0000-0001-8591-8010
Jessica VellaUrology Section, Department of Surgery, University of Catania, 95125 Catania, Italy.
Arturo Lo GiudiceUrology Section, Department of Surgery, University of Catania, 95125 Catania, Italy.ORCID 0000-0003-1987-929X
Maria Giovanna AsmundoUrology Section, Department of Surgery, University of Catania, 95125 Catania, Italy.ORCID 0000-0001-8248-6857
Sebastiano CiminoUrology Section, Department of Surgery, University of Catania, 95125 Catania, Italy.
Giuseppe MorgiaUrology Section, Department of Surgery, University of Catania, 95125 Catania, Italy.
Stefania StefaniDepartment of Biomedical and Biotechnological Sciences (BIOMETEC), University of Catania, 95125 Catania, Italy.ORCID 0000-0003-1594-7427
Nicolò MussoDepartment of Biomedical and Biotechnological Sciences (BIOMETEC), University of Catania, 95125 Catania, Italy.ORCID 0000-0003-2451-1158
University of Catania · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundProstate cancer (PCa) is a disease with a wide range of clinical manifestations. Up to the present date, the genetic understanding of patients with favorable or unfavorable prognosis is gaining interest for giving the appropriate tailored treatment. We aimed to investigate genetic changes associated with lymph node metastasis in a cohort of hormone-naïve Pca patients.

methodsWe retrospectively analyzed data from 470 patients who underwent surgery for PCa between 2010 and 2020 at the Department of Urology, University of Catania. Inclusion criteria were patients with lymph node metastasis and patients with PCa with extra capsular extension (pT3) and negative lymph node metastasis. The final cohort consisted of 17 different patients (11 PCa with lymph node metastasis and 6 PCa without lymph node metastasis). Through the cBioPortal online tool, we analyzed gene alterations and their correlations with clinical factors.

resultsA total of 688 intronic, synonym and nonsynonym mutations were sequenced. The gene with the most sequenced mutations was ERBB4 (83 mutations, 12% of 688 total), while the ones with the lower percentage of mutations were AKT1, FGFR2 and MLH1 (1 mutation alone, 0.14%).

conclusionIn the present study we found mostly concordance concerning the

Indexed as

ABL1CTNNB1ERBB4HRASKITnext generation sequencingoutcomeprognosisradical prostatectomy

Identifiers

PMID36077746
PMCPMC9454441
OpenAlexW4293777011

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.