ReviewInternational journal of molecular sciences2022
Ocular Lymphatic and Glymphatic Systems: Implications for Retinal Health and Disease.
Review in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 24 citations in OpenAlex.
- Article
- Migration of perivenous opacities during retinal vasculopathy and retinal vasculitis.American journal of ophthalmology case reports · 2026Article
- Glymphatic system impairment in dysthyroid optic neuropathy: relation with ocular cerebrospinal fluid circulation and visual function.Japanese journal of radiology · 2026Article
- Modulation of Systemic Osmolarity Alters Retinal Thickness and Schisis Cavities Without Blood Retinal Barrier Disruption in Rs1 Knockout Mice.Investigative ophthalmology & visual science · 2026Article
- Ocular Lymphatics in Health and Disease.Diagnostics (Basel, Switzerland) · 2026Review
- Towards a Deeper Understanding of Cerebrospinal Fluid Transport in the Optic Nerve Subarachnoid Space: A Computational Approach.Annals of biomedical engineering · 2026Article
- Ocular Glymphatic System: Its Modulation and Role in Intraocular Tumors.Investigative ophthalmology & visual science · 2026Review
- Neurovascular Coupling Disruption and Glymphatic Dysfunction Are Associated With Visual Impairment in Pediatric Monocular Anisometropic Amblyopia.Investigative ophthalmology & visual science · 2026Article
- Glymphatic Clearance in the Optic Nerve: A Multidomain Electro-Osmostic Model.Entropy (Basel, Switzerland) · 2025Article
- Drainage of subconjunctival hemorrhage through conjunctival lymphatic pathways.American journal of ophthalmology case reports · 2025Article
- Absorption of Toxicants from the Ocular Surface: Potential Applications in Toxicology.Biomedicines · 2025Review
- Advances in the Understanding of ocular and nasal lymphatics.BMC immunology · 2025Review
- Age-Related Macular Degeneration and Circadian Preference.Clinical ophthalmology (Auckland, N.Z.) · 2025Article
- Glymphatic system dysfunction in cerebral infarction: advances and perspectives based on DTI-derived ALPS measures.American journal of translational research · 2025Review
- Ocular-cerebral immune dialogue: a new perspective and therapeutic potential of regional lymphatic systems.Frontiers in immunology · 2025Review
- Transport of β-amyloid from brain to eye causes retinal degeneration in Alzheimer's disease.The Journal of experimental medicine · 2024Article
- Macular exudate in idiopathic intracranial hypertension affects outer retina and visual acuity.BMJ open ophthalmology · 2024Article
- Alzheimer's disease pathophysiology in the Retina.Progress in retinal and eye research · 2024Review
- Contribution of Direct Cerebral Vascular Transport in Brain Substance Clearance.Aging and disease · 2024Review
- Ontogenesis of the Mouse Ocular Surface Lymphatic Vascular Network.Investigative ophthalmology & visual science · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Clearance of ocular fluid and metabolic waste is a critical function of the eye in health and disease. The eye has distinct fluid outflow pathways in both the anterior and posterior segments. Although the anterior outflow pathway is well characterized, little is known about posterior outflow routes. Recent studies suggest that lymphatic and glymphatic systems play an important role in the clearance of fluid and waste products from the posterior segment of the eye. The lymphatic system is a vascular network that runs parallel to the blood circulatory system. It plays an essential role in maintenance of fluid homeostasis and immune surveillance in the body. Recent studies have reported lymphatics in the cornea (under pathological conditions), ciliary body, choroid, and optic nerve meninges. The evidence of lymphatics in optic nerve meninges is, however, limited. An alternative lymphatic system termed the glymphatic system was recently discovered in the rodent eye and brain. This system is a glial cell-based perivascular network responsible for the clearance of interstitial fluid and metabolic waste. In this review, we will discuss our current knowledge of ocular lymphatic and glymphatic systems and their role in retinal degenerative diseases.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.