ArticleInternational journal of molecular sciences2022
Small RNA-Seq Reveals Similar miRNA Transcriptome in Children and Young Adults with T-ALL and Indicates miR-143-3p as Novel Candidate Tumor Suppressor in This Leukemia.
Article in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.6field-weighted citation impact, top 36% of its field
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literature
Who cites it
5 citing papers in PubMed, 7 citations in OpenAlex.
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what money
Authors and funding
16 authors at 7 institutions in 1 country.
Małgorzata DawidowskaInstitute of Human Genetics, Polish Academy of Sciences, 60-479 Poznan, Poland.ORCID 0000-0003-3486-6577
Natalia Maćkowska-MaślakInstitute of Human Genetics, Polish Academy of Sciences, 60-479 Poznan, Poland.ORCID 0000-0002-0296-4597
Monika Drobna-ŚledzińskaInstitute of Human Genetics, Polish Academy of Sciences, 60-479 Poznan, Poland.ORCID 0000-0003-1671-9071
Maria KosmalskaInstitute of Human Genetics, Polish Academy of Sciences, 60-479 Poznan, Poland.
Roman JaksikDepartment of Systems Biology and Engineering, Silesian University of Technology, 44-100 Gliwice, Poland.ORCID 0000-0003-1866-6380
Donata SzymczakDepartment and Clinic of Hematology, Blood Neoplasms, and Bone Marrow Transplantation, Wroclaw Medical University, 50-367 Wroclaw, Poland.
Małgorzata Jarmuż-SzymczakInstitute of Human Genetics, Polish Academy of Sciences, 60-479 Poznan, Poland.ORCID 0000-0003-0437-5806
Alicja Sadowska-KlasaDepartment of Hematology and Transplantology, Medical University of Gdańsk, 80-210 Gdansk, Poland.
Marzena WojtaszewskaDepartment of Hematology and Bone Marrow Transplantation, Poznan University of Medical Sciences, 60-569 Poznan, Poland.
Łukasz SędekDepartment of Microbiology and Immunology, Zabrze, Medical University of Silesia in Katowice, 40-055 Katowice, Poland.ORCID 0000-0001-9384-914X
Tomasz WróbelDepartment and Clinic of Hematology, Blood Neoplasms, and Bone Marrow Transplantation, Wroclaw Medical University, 50-367 Wroclaw, Poland.
Jan Maciej ZauchaDepartment of Hematology and Transplantology, Medical University of Gdańsk, 80-210 Gdansk, Poland.ORCID 0000-0002-0986-8936
Tomasz SzczepańskiDepartment of Pediatric Hematology and Oncology, Zabrze, Medical University of Silesia in Katowice, 40-055 Katowice, Poland.ORCID 0000-0001-5336-261X
Krzysztof LewandowskiDepartment of Hematology and Bone Marrow Transplantation, Poznan University of Medical Sciences, 60-569 Poznan, Poland.ORCID 0000-0003-0992-2020
Sebastian GiebelDepartment of Bone Marrow Transplantation and Onco-Hematology, Maria Sklodowska-Curie National Research Institute of Oncology, Gliwice Branch, 44-102 Gliwice, Poland.
Michał WittInstitute of Human Genetics, Polish Academy of Sciences, 60-479 Poznan, Poland.
Institute of Human Genetics · PLPoznan University of Medical Sciences · PLGdańsk Medical University · PLMedical University of Silesia · PLWroclaw Medical University · PLSilesian University of Technology · PLThe Maria Sklodowska-Curie National Research Institute of Oncology · PL
Funding
European Union's Horizon 2020 research and innovation programme Grant Agreement No. 952304National Centre for Research and Development STRATEGMED3/304586/5/NCBR/2017National Science Center 2014/15/B/NZ2/03394National Science Center 2016/23/D/ST7/03665National Science Center 2017/25/N/NZ2/01132National Science Center 2018/02/X/NZ2/01833National Science Center 2021/41/N/NZ2/02247
6 · The paper itself
Abstract
We aimed to identify miRNAs and pathways specifically deregulated in adolescent and young adult (AYA) T-ALL patients. Small RNA-seq showed no major differences between AYA and pediatric T-ALL, but it revealed downregulation of miR-143-3p in T-ALL patients. Prediction algorithms identified several known and putative oncogenes targeted by this miRNA, including
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.