Evidence map›Paper›PMID 36077512›Full record

ArticleInternational journal of molecular sciences2022

Reversible Photocontrol of Dopaminergic Transmission in Wild-Type Animals.

Carlo Matera, Pablo Calvé, Verònica Casadó-Anguera, Rosalba Sortino, Alexandre M J Gomila, Estefanía Moreno, Thomas Gener, Cristina Delgado-Sallent, Pau Nebot, Davide Costazza and 6 more

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.8field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 12 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Review
  5. Light-Controlled Modulation and Analysis of Neuronal Functions.International journal of molecular sciences · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 8 institutions in 2 countries.

Carlo MateraInstitute for Bioengineering of Catalonia (IBEC), the Barcelona Institute for Science and Technology, 08028 Barcelona, Spain.ORCID 0000-0001-6939-3859
Pablo CalvéHospital del Mar Medical Research Institute (IMIM), Barcelona Biomedical Research Park, 08003 Barcelona, Spain.
Verònica Casadó-AngueraDepartment of Biochemistry and Molecular Biomedicine, Faculty of Biology, Institute of Biomedicine, University of Barcelona, 08028 Barcelona, Spain.
Rosalba SortinoInstitute for Bioengineering of Catalonia (IBEC), the Barcelona Institute for Science and Technology, 08028 Barcelona, Spain.
Alexandre M J GomilaInstitute for Bioengineering of Catalonia (IBEC), the Barcelona Institute for Science and Technology, 08028 Barcelona, Spain.
Estefanía MorenoDepartment of Biochemistry and Molecular Biomedicine, Faculty of Biology, Institute of Biomedicine, University of Barcelona, 08028 Barcelona, Spain.ORCID 0000-0002-2491-5753
Thomas GenerHospital del Mar Medical Research Institute (IMIM), Barcelona Biomedical Research Park, 08003 Barcelona, Spain.
Cristina Delgado-SallentHospital del Mar Medical Research Institute (IMIM), Barcelona Biomedical Research Park, 08003 Barcelona, Spain.
Pau NebotHospital del Mar Medical Research Institute (IMIM), Barcelona Biomedical Research Park, 08003 Barcelona, Spain.
Davide CostazzaInstitute for Bioengineering of Catalonia (IBEC), the Barcelona Institute for Science and Technology, 08028 Barcelona, Spain.
Sara Conde-BerriozabalDepartment of Biomedical Sciences, Faculty of Medicine and Health Sciences, Institute of Neuroscience, University of Barcelona, IDIBAPS, CIBERNED, 08036 Barcelona, Spain.
Mercè MasanaDepartment of Biomedical Sciences, Faculty of Medicine and Health Sciences, Institute of Neuroscience, University of Barcelona, IDIBAPS, CIBERNED, 08036 Barcelona, Spain.ORCID 0000-0003-1392-4774
Jordi HernandoDepartment of Chemistry, Autonomous University of Barcelona (UAB), 08193 Cerdanyola del Vallès, Spain.
Vicent CasadóDepartment of Biochemistry and Molecular Biomedicine, Faculty of Biology, Institute of Biomedicine, University of Barcelona, 08028 Barcelona, Spain.ORCID 0000-0002-1764-3825
M Victoria PuigHospital del Mar Medical Research Institute (IMIM), Barcelona Biomedical Research Park, 08003 Barcelona, Spain.
Pau GorostizaInstitute for Bioengineering of Catalonia (IBEC), the Barcelona Institute for Science and Technology, 08028 Barcelona, Spain.ORCID 0000-0002-7268-5577
Barcelona Biomedical Research Park · ESInstitute for Research in Biomedicine · ESBiomedical Research Networking Center in Bioengineering, Biomaterials and Nanomedicine · ESConsorci Institut D'Investigacions Biomediques August Pi I Sunyer · ESBarcelona Institute of Science and Technology · ESInstitució Catalana de Recerca i Estudis Avançats · ESUniversitat Autònoma de Barcelona · ESUniversity of Milan · IT

Funding

AGAUR/Generalitat de Catalunya CERCA ProgrammeEU Horizon 2020 Framework Programme for Research and Innovation Human Brain Project WaveScalES, Specific Grant Agreement 2 No. 785907; NEUROPA project, Grant Agreement No. 863214European Union Regional Development Fund within the framework of the ERDF Operational Program of Catalonia 2014-2020 CECH projectGeneralitat de Catalunya Grant no. 2017-SGR-1497 to V.C., 2017-SGR-210 to M.V.P., and 2017-SGR-00465 to J.H.Ministerio de Economía y Competitividad and European Regional Development Funds Grant no. SAF2017-87629-R to V.C., SAF2016-80726-R to M.V.P., SAF2017-88076-R to M.M.
6 · The paper itself

Abstract

Understanding the dopaminergic system is a priority in neurobiology and neuropharmacology. Dopamine receptors are involved in the modulation of fundamental physiological functions, and dysregulation of dopaminergic transmission is associated with major neurological disorders. However, the available tools to dissect the endogenous dopaminergic circuits have limited specificity, reversibility, resolution, or require genetic manipulation. Here, we introduce azodopa, a novel photoswitchable ligand that enables reversible spatiotemporal control of dopaminergic transmission. We demonstrate that azodopa activates D

Indexed as

Animals, WildZebrafishAnimalsDopamineLigandsMiceSynaptic TransmissionDopamineLigandsazobenzenebehaviorbrainwavedopamineGPCRin vivo electrophysiologyoptogeneticsoptopharmacologyphotochromismphotopharmacologyphotoswitchzebrafish

Identifiers

PMID36077512
PMCPMC9456102
OpenAlexW4294733117

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.