ArticleInternational journal of molecular sciences2022
Cottonseed Meal Protein Isolate as a New Source of Alternative Proteins: A Proteomics Perspective.
Article in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Genome-wide association study reveals stable loci and candidate genes for cottonseed protein content in upland cotton (Gossypium hirsutum L.).TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2026Article
- Cottonseed proteins: A promising and undervalued non-grain protein source for aquafeed.Animal nutrition (Zhongguo xu mu shou yi xue hui) · 2026Review
- Improved quality of cottonseed meal: effect of cottonseed protein isolate on growth performance, nutrient digestibility, and intestinal health in growing pigs.Journal of animal science · 2025Article
- Cottonseed protein concentrate as an effective substitute to fish meal in pike perch (Frontiers in immunology · 2025Article
- An Empirical Analysis of Sacha Inchi (Plantae: Plukenetia volubilis L.) Seed Proteins and Their Applications in the Food and Biopharmaceutical Industries.Applied biochemistry and biotechnology · 2024Article
- Rumen Microbiota Transplantation Alleviates Gossypol Diet-Induced Reproductive, Liver, and Intestinal Damage in Male Mice.Animals : an open access journal from MDPI · 2024Article
- Effects of high-pressure homogenization and ultrasound on the composition, structure, and physicochemical properties of proteins extracted from Nannochloropsis Oceania.Ultrasonics sonochemistry · 2024Article
- Fractionation and Lability of Phosphorus Species in Cottonseed Meal-Derived Biochars as Influenced by Pyrolysis Temperature.Molecules (Basel, Switzerland) · 2024Article
- Dietary Effects of Fermented Cottonseed Meal Substituting Fishmeal on the Growth, Biochemical Indexes, Antioxidant Capacity, and Muscle Quality of Juvenile Golden Pompano (Aquaculture nutrition · 2024Article
- The Effects of Oil Content on the Structural and Textural Properties of Cottonseed Butter/Spread Products.Foods (Basel, Switzerland) · 2023Article
- Characterization of the Nonpolar and Polar Extractable Components of Glanded Cottonseed for Its Valorization.Molecules (Basel, Switzerland) · 2023Article
- Cross-Serological Reaction of Glandless Cottonseed Proteins to Peanut and Tree Nut Allergic IgE.Molecules (Basel, Switzerland) · 2023Article
- Plant Proteomic Research 5.0: From Data to Insights.International journal of molecular sciences · 2022Article
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Authors and funding
6 authors.
Funding
Abstract
Cottonseed meal (CSM) is a good source of dietary proteins but is unsuitable for human consumption due to its gossypol content. To unlock its potential, we developed a protein extraction process with a gossypol removal treatment to generate CSM protein isolate (CSMPI) with ultra-low gossypol content. This process successfully reduced the free and total gossypol content to 4.8 ppm and 147.2 ppm, respectively, far below the US FDA limit. In addition, the functional characterisation of CSMPI revealed a better oil absorption capacity and water solubility than pea protein isolate. Proteome profiling showed that the treatment improved protein identification, while SDS-PAGE analysis indicated that the treatment did not induce protein degradation. Amino acid analysis revealed that post-treated CSMPI was rich in branched-chain amino acids (BCAAs). Mass spectrometry analysis of various protein fractions obtained from an in vitro digestibility assay helped to establish the digestibility profile of CSM proteins. Several potential allergens in CSMPI were also found using allergenic prediction software, but further evaluation based on their digestibility profiles and literature reviews suggests that the likelihood of CSMPI allergenicity remains low. Overall, our results help to navigate and direct the application of CSMPIs as alternative proteins toward nutritive human food application.
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