ArticleInternational journal of molecular sciences2022
Expression of Eosinophilic Subtype Markers in Patients with Kawasaki Disease.
Article in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 8 citations in OpenAlex.
- Predictive value of blood composite ratios for Kawasaki disease and coronary artery lesions in febrile children.Italian journal of pediatrics · 2025Article
- Heterogeneity in Kawasaki disease patients with coronary artery abnormalities investigated by data-driven cluster analysis.Pediatric research · 2025Article
- Interpretable web-based machine learning model for predicting intravenous immunoglobulin resistance in Kawasaki disease.Italian journal of pediatrics · 2025Article
- Development and validation of an explainable machine learning-based prediction model for primary Kawasaki disease complicated with coronary artery aneurysms.Translational pediatrics · 2025Article
- Expression of Serum Ferritin, Human neutrophil lipocalin, Procalcitonin, and inflammatory factors in children with Kawasaki disease and their relationship to coronary artery lesions.American journal of translational research · 2025Article
- Identifying the risk of Kawasaki disease based solely on routine blood test features through novel construction of machine learning models.Computational and structural biotechnology journal · 2025Article
- Basophils Predict Mite Sensitization in Patients with Kawasaki Disease.Children (Basel, Switzerland) · 2023Article
- Use of Machine Learning to Differentiate Children With Kawasaki Disease From Other Febrile Children in a Pediatric Emergency Department.JAMA network open · 2023Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
purposeEosinophils may rise to a higher level in the acute phase of Kawasaki disease (KD) both before and after intravenous immunoglobulin (IVIG) therapy. A substantial body of research was carried out on the association between KD and allergic diseases. Eosinophils play an important role in type 2 inflammation. Recent studies have shown that there are two distinct subtypes of eosinophils. In addition to their role in inflammation, lung-resident eosinophils (rEOS) also regulate homeostasis. Inflammatory eosinophils (iEOS) reflect type 2 inflammation in tissues. iEOS were considered the primary eosinophils in non-severe allergic asthma, while rEOS were thought to be the primary eosinophils in severe non-allergic eosinophilic asthma. This case-control study aimed to investigate the marker expression of eosinophilic subtypes in KD patients. MATERIALS AND
methodsThe marker expressions of eosinophilic subtypes in the leukocytes of patients with KD were evaluated by the recently established KDmarkers online tool, a web server including gene expression data. Finally, the results were validated with a quantitative reverse transcriptase polymerase chain reaction (RT-PCR). We analyzed the mRNA expression levels of
resultsIncluded in our screening tools were transcriptome arrays, which provided clues showing the importance of rEOS, whose role was identified by three genes (lower
conclusionsTo our knowledge, this is the first study to demonstrate that KD patients have increased
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