ReviewInternational journal of molecular sciences2022
Salivary Redox Homeostasis in Human Health and Disease.
Review in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Compartment-specific oxidative stress signatures in oral leukoplakia: a systematic review of local and systemic biomarkers.Frontiers in physiology · 2026Pooled it
- Potential of Saliva in Stroke Patients: A Review.International journal of molecular sciences · 2026Review
- Oxidative Stress Biomarkers in Oral Mucosal Wound Healing and Photobiomodulation: Biochemical Pathways, Experimental Models, and Translational Perspectives.International journal of molecular sciences · 2026Review
- GLP-1 Receptor Agonists in Periodontology: Mechanisms, Clinical Evidence, and Implications for Care.Biomolecules · 2026Review
- Heavy Metal-Driven Oral Dysbiosis: Salivary Toxicometallomics at the Host-Microbiome Interface Across Pathologies.Life (Basel, Switzerland) · 2026Review
- Article
- Salivary Oxidative Stress and Antioxidant Markers in Oral Leukoplakia: A Systematic Review and Meta-Analysis.Antioxidants (Basel, Switzerland) · 2026Review
- The Role of Oxidative Stress and Total Antioxidant Capacity in the Management of Impacted Third Molars: A Narrative Review.Dentistry journal · 2026Review
- Evaluation of Oxidative Stress Markers in Post-Surgical Head and Neck Cancer Patients Rehabilitated with Removable Prosthetic Restorations.Antioxidants (Basel, Switzerland) · 2025Article
- High Salivary 3-Nitrotyrosine Levels in Periodontitis.Journal of clinical medicine · 2025Article
- The Role of Oxidative Stress-Related Gene Polymorphisms (Medicina (Kaunas, Lithuania) · 2025Article
- Analyzing the Biochemistry of Saliva: Flow, Total Protein, Amylase Enzymatic Activity, and Their Interconnections.International journal of molecular sciences · 2025Article
- Bioaccessibility of Cafestol from Coffee Brew: A Metabolic Study Employing anJournal of agricultural and food chemistry · 2024Article
- Total Antioxidant Status in Critically Ill Patients with Traumatic Brain Injury and Secondary Organ Failure-A Systematic Review.Diagnostics (Basel, Switzerland) · 2024Review
- Saliva as a Diagnostic Tool for Early Detection of Exercise-Induced Oxidative Damage in Female Athletes.Biomedicines · 2024Article
- Salivary diagnostics: opportunities and challenges.Theranostics · 2024Review
- Electronic Tongue for Direct Assessment of SARS-CoV-2-Free and Infected Human Saliva-A Feasibility Study.Biosensors · 2023Article
- Special Issue "Role of Redox Homeostasis and Oxidative Stress in Human Health".International journal of molecular sciences · 2023Article
- The Emerging Role of Salivary Oxidative Stress Biomarkers as Prognostic Markers of Periodontitis: New Insights for a Personalized Approach in Dentistry.Journal of personalized medicine · 2023Review
- Signaling pathways of oxidative stress response: the potential therapeutic targets in gastric cancer.Frontiers in immunology · 2023Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
Homeostasis is a self-regulatory dynamic process that maintains a stable internal environment in the human body. These regulations are essential for the optimal functioning of enzymes necessary for human health. Homeostasis elucidates disrupted mechanisms leading to the development of various pathological conditions caused by oxidative stress. In our work, we discuss redox homeostasis and salivary antioxidant activity during healthy periods and in periods of disease: dental carries, oral cavity cancer, periodontal diseases, cardiovascular diseases, diabetes mellitus, systemic sclerosis, and pancreatitis. The composition of saliva reflects dynamic changes in the organism, which makes it an excellent tool for determining clinically valuable biomarkers. The oral cavity and saliva may form the first line of defense against oxidative stress. Analysis of salivary antioxidants may be helpful as a diagnostic, prognostic, and therapeutic marker of not only oral, but also systemic health.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.