Evidence map›Paper›PMID 36077454›Full record

ArticleInternational journal of molecular sciences2022

Sodium-Calcium Exchanger 2: A Pivotal Role in Oxaliplatin Induced Peripheral Neurotoxicity and Axonal Damage?

Elisa Ballarini, Alessio Malacrida, Virginia Rodriguez-Menendez, Eleonora Pozzi, Annalisa Canta, Alessia Chiorazzi, Laura Monza, Sara Semperboni, Cristina Meregalli, Valentina Alda Carozzi and 6 more

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
2.0field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 21 citations in OpenAlex.

  1. Article
  2. Oxaliplatin-induced peripheral neuropathy: from pathogenesis to treatment.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 2 institutions in 2 countries.

Elisa BallariniSchool of Medicine and Surgery, University of Milano-Bicocca, 20126 Milan, Italy.
Alessio MalacridaSchool of Medicine and Surgery, University of Milano-Bicocca, 20126 Milan, Italy.
Virginia Rodriguez-MenendezSchool of Medicine and Surgery, University of Milano-Bicocca, 20126 Milan, Italy.
Eleonora PozziSchool of Medicine and Surgery, University of Milano-Bicocca, 20126 Milan, Italy.ORCID 0000-0001-6438-286X
Annalisa CantaSchool of Medicine and Surgery, University of Milano-Bicocca, 20126 Milan, Italy.
Alessia ChiorazziSchool of Medicine and Surgery, University of Milano-Bicocca, 20126 Milan, Italy.ORCID 0000-0002-3469-1829
Laura MonzaSchool of Medicine and Surgery, University of Milano-Bicocca, 20126 Milan, Italy.
Sara SemperboniSchool of Medicine and Surgery, University of Milano-Bicocca, 20126 Milan, Italy.
Cristina MeregalliSchool of Medicine and Surgery, University of Milano-Bicocca, 20126 Milan, Italy.ORCID 0000-0002-4281-4577
Valentina Alda CarozziSchool of Medicine and Surgery, University of Milano-Bicocca, 20126 Milan, Italy.ORCID 0000-0003-0963-7107
Maryamsadat HashemiSchool of Medicine and Surgery, University of Milano-Bicocca, 20126 Milan, Italy.
Gabriella NicoliniSchool of Medicine and Surgery, University of Milano-Bicocca, 20126 Milan, Italy.ORCID 0000-0002-6241-4538
Arianna ScuteriSchool of Medicine and Surgery, University of Milano-Bicocca, 20126 Milan, Italy.ORCID 0000-0003-0240-313X
Stephen N HousleyIntegrated Cancer Research Center, School of Biological Sciences, Georgia Institute of Technology, Atlanta, GA 30332, USA.
Guido CavalettiSchool of Medicine and Surgery, University of Milano-Bicocca, 20126 Milan, Italy.ORCID 0000-0003-4128-2406
Paola AlbertiSchool of Medicine and Surgery, University of Milano-Bicocca, 20126 Milan, Italy.ORCID 0000-0001-6106-6183
University of Milano-Bicocca · ITGeorgia Institute of Technology · US

Funding

Multiscale models of proprioceptive encoding to reveal mechanisms of impaired sensorimotor controlR01HD090642 · NICHD · EMORY UNIVERSITY · PI COPE, TIMOTHY C, SAWICKI, GREGORY STEPHEN · 2016 to 2025
$4.9M
Mechanisms underlying spontaneous firing by motoneurons with acute neurotoxicityR01CA268125 · NCI · GEORGIA INSTITUTE OF TECHNOLOGY · PI Timothy C Cope · 2022 to 2026
$2.4M
Novel Path to Chronic Sensorimotor Dysfunction and Treatment for ChemotherapyR01CA221363 · NCI · GEORGIA INSTITUTE OF TECHNOLOGY · PI COPE, TIMOTHY C · 2018 to 2022
$1.5M
MUR/PRIN 2017ZFJCS3NCI NIH HHS R01 CA221363NCI NIH HHS R01 CA268125NICHD NIH HHS R01 HD090642UNIMIB 2020-ATESP-0110UNIMIB 2021-ATESP-0042
6 · The paper itself

Abstract

Oxaliplatin (OHP)-induced peripheral neurotoxicity (OIPN) is a frequent adverse event of colorectal cancer treatment. OIPN encompasses a chronic and an acute syndrome. The latter consists of transient axonal hyperexcitability, due to unbalance in Na

Indexed as

Neurotoxicity SyndromesSodium-Calcium ExchangerAnimalsAxonsMiceOxaliplatinPilot ProjectsRatsOxaliplatinSlc8a2 protein, mouseSlc8a2 protein, ratSodium-Calcium Exchangeraxonal damageaxonal hyperexcitabilitychemotherapy induced peripheral neuropathychemotherapy-induced peripheral neurotoxicityimmunofluorescenceimmunohistochemistryNCX2nerve excitability testingneuropathologyneuroprotectionvoltage-operated ion channels

Identifiers

PMID36077454
PMCPMC9456447
OpenAlexW4294733259

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.