Evidence map›Paper›PMID 36077450›Full record

ArticleInternational journal of molecular sciences2022

Development of Methotrexate Complexes Endowed with New Biological Properties Envisioned for Musculoskeletal Regeneration in Rheumatoid Arthritis Environments.

Daniel Fernández-Villa, Rosa Ana Ramírez-Jiménez, Inmaculada Aranaz, Niuris Acosta, Blanca Vázquez-Lasa, Luis Rojo

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.2field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 9 citations in OpenAlex.

  1. Review
  2. Approaches Towards Better Immunosuppressive Agents.Current topics in medicinal chemistry · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Daniel Fernández-VillaInstituto de Ciencia y Tecnología de Polímeros (ICTP) CSIC, 28006 Madrid, Spain.ORCID 0000-0001-7420-9104
Rosa Ana Ramírez-JiménezInstituto de Ciencia y Tecnología de Polímeros (ICTP) CSIC, 28006 Madrid, Spain.ORCID 0000-0001-7563-2553
Inmaculada AranazInstituto Pluridisciplinar, Departamento de Química en Ciencias Farmacéuticas, Facultad de Farmacia, Universidad Complutense de Madrid, 28040 Madrid, Spain.ORCID 0000-0002-1495-9744
Niuris AcostaInstituto Pluridisciplinar, Departamento de Química en Ciencias Farmacéuticas, Facultad de Farmacia, Universidad Complutense de Madrid, 28040 Madrid, Spain.ORCID 0000-0001-5145-8781
Blanca Vázquez-LasaInstituto de Ciencia y Tecnología de Polímeros (ICTP) CSIC, 28006 Madrid, Spain.ORCID 0000-0001-5539-8026
Luis RojoInstituto de Ciencia y Tecnología de Polímeros (ICTP) CSIC, 28006 Madrid, Spain.ORCID 0000-0001-6334-6736
Instituto de Ciencia y Tecnología de Polímeros · ESUniversidad Complutense de Madrid · ES

Funding

Spanish MICINN FPU18/04683Spanish MICINN MAT201573656-JINSpanish MICINN PID2019-105337RB-C22Spanish MICINN PID2020-114086RB-100
6 · The paper itself

Abstract

Methotrexate (MTX) administration is the gold standard treatment for rheumatoid arthritis (RA), but its effects are limited to preventing the progression of the disease. Therefore, effective regenerative therapies for damaged tissues are still to be developed. In this regard, MTX complexes of general molecular formula M(MTX)·xH

Indexed as

Antirheumatic AgentsArthritis, RheumatoidAnti-Inflammatory AgentsHumansMacrophagesMethotrexateAnti-Inflammatory AgentsAntirheumatic AgentsMethotrexateanti-inflammatory propertieschitosanglycosaminoglycansmagnesiummethotrexatemicroparticlesnitric oxidestrontiumzinc

Identifiers

PMID36077450
PMCPMC9456012
OpenAlexW4294740836

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.