Evidence map›Paper›PMID 36077447›Full record

ArticleInternational journal of molecular sciences2022

ASC Regulates Subcutaneous Adipose Tissue Lipogenesis and Lipolysis via p53/AMPKα Axis.

Hong Chen, Qilin Pei, Linfen Tao, Jing Xia, Guocai Lu, Ying Zong, Wenhua Xie, Wanqing Li, Chenglong Huang, Ting Zeng and 6 more

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.3field-weighted citation impact, top 48% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 3 institutions in 1 country.

Hong ChenInstitute of Life Sciences, School of Basic Medicine, Chongqing Medical University, Chongqing 400016, China.
Qilin PeiInstitute of Life Sciences, School of Basic Medicine, Chongqing Medical University, Chongqing 400016, China.
Linfen TaoDepartment of Laboratory Medicine, School of Medical Technology and Engineering, Fujian Medical University, Fuzhou 350001, China.
Jing XiaInstitute of Life Sciences, School of Basic Medicine, Chongqing Medical University, Chongqing 400016, China.
Guocai LuDepartment of Health Toxicology, Faculty of Naval Medicine, Second Military Medical University, Shanghai 200433, China.
Ying ZongDepartment of Health Toxicology, Faculty of Naval Medicine, Second Military Medical University, Shanghai 200433, China.
Wenhua XieInstitute of Life Sciences, School of Basic Medicine, Chongqing Medical University, Chongqing 400016, China.
Wanqing LiInstitute of Life Sciences, School of Basic Medicine, Chongqing Medical University, Chongqing 400016, China.
Chenglong HuangInstitute of Life Sciences, School of Basic Medicine, Chongqing Medical University, Chongqing 400016, China.
Ting ZengInstitute of Life Sciences, School of Basic Medicine, Chongqing Medical University, Chongqing 400016, China.
Xinyu YuInstitute of Life Sciences, School of Basic Medicine, Chongqing Medical University, Chongqing 400016, China.
Weixuan WangInstitute of Life Sciences, School of Basic Medicine, Chongqing Medical University, Chongqing 400016, China.
Gaojun ChenInstitute of Life Sciences, School of Basic Medicine, Chongqing Medical University, Chongqing 400016, China.
Song YangInstitute of Life Sciences, School of Basic Medicine, Chongqing Medical University, Chongqing 400016, China.
Rui ChengInstitute of Life Sciences, School of Basic Medicine, Chongqing Medical University, Chongqing 400016, China.
Xi LiInstitute of Life Sciences, School of Basic Medicine, Chongqing Medical University, Chongqing 400016, China.ORCID 0000-0002-2716-7308
Chongqing Medical University · CNSecond Military Medical University · CNFujian Medical University · CN

Funding

Rui Cheng 20210123Song Yang 20180151Song Yang cstc2020jcyj-msxmX0306Xi Li National Key R&D Program of China (2018YFA0800401);National Natural Science Foundation of China (No. 81770861, 82070899, and 82011530460)
6 · The paper itself

Abstract

Obesity has become an extensive threat to human health due to associated chronic inflammation and metabolic diseases. Apoptosis-associated speck-like protein (ASC) is a critical link between inflammasome and apoptosis-inducing proteins. In this study, we aimed to clarify the role of ASC in lipid metabolism. With high-fat diet (HFD) and knockout leptin gene mice (

Indexed as

LipogenesisLipolysisAdipose TissueAMP-Activated Protein KinasesAnimalsDiet, High-FatHumansLipidsMiceObesitySubcutaneous FatTumor Suppressor Protein p53AMP-Activated Protein KinasesLipidsTumor Suppressor Protein p53AMPKαASClipogenesislipolysisp53

Identifiers

PMID36077447
PMCPMC9456541
OpenAlexW4294739798

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.