Evidence map›Paper›PMID 36077441›Full record

ArticleInternational journal of molecular sciences2022

Optimization of Signal Peptide via Site-Directed Mutagenesis for Enhanced Secretion of Heterologous Proteins in

Nur Aqlili Riana Alias, Adelene Ai-Lian Song, Noorjahan Banu Alitheen, Raha Abdul Rahim, Siti Sarah Othman, Lionel Lian Aun In

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.7field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Pharmaceutics · 2026
    Review
  3. Review
  4. Review
  5. Article
  6. Article
  7. Effect of Secretion Efficiency of Mutant KRAS Neoantigen byInternational journal of molecular sciences · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Nur Aqlili Riana AliasDepartment of Cell and Molecular Biology, Faculty of Biotechnology and Biomolecular Sciences, Universiti Putra Malaysia, Serdang 43400, Malaysia.ORCID 0000-0002-3741-7411
Adelene Ai-Lian SongDepartment of Microbiology, Faculty of Biotechnology and Biomolecular Sciences, Universiti Putra Malaysia, Serdang 43400, Malaysia.ORCID 0000-0002-5413-3314
Noorjahan Banu AlitheenDepartment of Cell and Molecular Biology, Faculty of Biotechnology and Biomolecular Sciences, Universiti Putra Malaysia, Serdang 43400, Malaysia.
Raha Abdul RahimDepartment of Cell and Molecular Biology, Faculty of Biotechnology and Biomolecular Sciences, Universiti Putra Malaysia, Serdang 43400, Malaysia.
Siti Sarah OthmanDepartment of Cell and Molecular Biology, Faculty of Biotechnology and Biomolecular Sciences, Universiti Putra Malaysia, Serdang 43400, Malaysia.ORCID 0000-0001-5802-6359
Lionel Lian Aun InDepartment of Biotechnology, Faculty of Applied Sciences, UCSI University Kuala Lumpur, Cheras 56000, Malaysia.ORCID 0000-0001-7182-112X
Universiti Putra Malaysia · MYUCSI University · MY

Funding

Fundamental Research Grant Scheme of Ministry of Higher Education, Malaysia FRGS/5524330Putra Graduate Initiative Grant of University Putra Malaysia, Malaysia IPS-GPS/9450900
6 · The paper itself

Abstract

Secretion efficiency of heterologous proteins in the Generally Regarded As Safe (GRAS)

Indexed as

Lactococcus lactisBacterial ProteinsMutagenesis, Site-DirectedProtein Sorting SignalsStaphylococcus aureusBacterial ProteinsProtein Sorting Signalsheterologous protein productionLactococcus lactissecretion efficiencysignal peptidesite-directed mutagenesisSPK1Staphylococcal nuclease (NUC)USP45

Identifiers

PMID36077441
PMCPMC9456127
OpenAlexW4294739768

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.