Evidence map›Paper›PMID 36077435›Full record

ArticleInternational journal of molecular sciences2022

Transcription Factors Runx1 and Runx3 Suppress Keratin Expression in Undifferentiated Keratinocytes.

Eisaku Ogawa, Tomohiro Edamitsu, Hidetaka Ohmori, Kazuyoshi Kohu, Mineo Kurokawa, Hiroshi Kiyonari, Masanobu Satake, Ryuhei Okuyama

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.4field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Editorial: Special Issue, "Molecular Advances in Skin Diseases".International journal of molecular sciences · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

Eisaku OgawaDepartment of Dermatology, Shinshu University School of Medicine, Matsumoto 390-8621, Japan.
Tomohiro EdamitsuDepartment of Dermatology, Shinshu University School of Medicine, Matsumoto 390-8621, Japan.
Hidetaka OhmoriDepartment of Molecular Immunology, Institute of Development, Aging and Cancer, Tohoku University, Sendai 980-8575, Japan.
Kazuyoshi KohuDepartment of Molecular Immunology, Institute of Development, Aging and Cancer, Tohoku University, Sendai 980-8575, Japan.
Mineo KurokawaDepartment of Hematology and Oncology, Graduate School of Medicine, The University of Tokyo, Tokyo 113-0033, Japan.
Hiroshi KiyonariLaboratory for Animal Resources and Genetic Engineering, RIKEN Center for Biosystems Dynamics Research, Kobe 650-0047, Japan.ORCID 0000-0002-1509-8747
Masanobu SatakeDepartment of Molecular Immunology, Institute of Development, Aging and Cancer, Tohoku University, Sendai 980-8575, Japan.
Ryuhei OkuyamaDepartment of Dermatology, Shinshu University School of Medicine, Matsumoto 390-8621, Japan.ORCID 0000-0003-4360-6865
Shinshu University · JPTohoku University · JPRIKEN Center for Biosystems Dynamics Research · JPThe University of Tokyo · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The Runt-related transcription factor (Runx) family has been suggested to play roles in stem cell regulation, tissue development, and oncogenesis in various tissues/organs. In this study, we investigated the possible functions of Runx1 and Runx3 in keratinocyte differentiation. Both Runx1 and Runx3 proteins were detected in primary cultures of mouse keratinocytes. Proteins were localized in the nuclei of undifferentiated keratinocytes but translocated to the cytoplasm of differentiated cells. The siRNA-mediated inhibition of

Indexed as

Keratin-1Keratin-10AnimalsCell DifferentiationCore Binding Factor Alpha 2 SubunitCore Binding Factor Alpha 3 SubunitKeratinocytesKeratinsMiceCore Binding Factor Alpha 2 SubunitCore Binding Factor Alpha 3 SubunitKeratin-1Keratin-10KeratinsRunx1 protein, mouseRunx3 protein, mousedifferentiationkeratinocyteproliferationrunt-related transcription factor (Runx)

Identifiers

PMID36077435
PMCPMC9456233
OpenAlexW4294740388

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.