Evidence map›Paper›PMID 36077342›Full record

ArticleInternational journal of molecular sciences2022

Transcription Factor MAFB as a Prognostic Biomarker for the Lung Adenocarcinoma.

Omar Samir, Naohiro Kobayashi, Teppei Nishino, Mennatullah Siyam, Manoj Kumar Yadav, Yuri Inoue, Satoru Takahashi, Michito Hamada

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.7field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Case report:Frontiers in immunology · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 2 countries.

Omar SamirLaboratory Animal Resource Center in Transborder Medical Research Center, Faculty of Medicine, University of Tsukuba, 1-1-1 Tennodai, Tsukuba 305-8575, Japan.ORCID 0000-0002-2022-5069
Naohiro KobayashiDepartment of General Thoracic Surgery, Faculty of Medicine, University of Tsukuba, 1-1-1 Tennodai, Tsukuba 305-8575, Japan.ORCID 0000-0002-1663-8039
Teppei NishinoDepartment of Anatomy and Embryology, Faculty of Medicine, University of Tsukuba, 1-1-1 Tennodai, Tsukuba 305-8575, Japan.ORCID 0000-0003-2544-4639
Mennatullah SiyamDepartment of Anatomy and Embryology, Faculty of Medicine, University of Tsukuba, 1-1-1 Tennodai, Tsukuba 305-8575, Japan.
Manoj Kumar YadavDepartment of Anatomy and Embryology, Faculty of Medicine, University of Tsukuba, 1-1-1 Tennodai, Tsukuba 305-8575, Japan.ORCID 0000-0002-8603-6148
Yuri InoueDepartment of Anatomy and Embryology, Faculty of Medicine, University of Tsukuba, 1-1-1 Tennodai, Tsukuba 305-8575, Japan.
Satoru TakahashiLaboratory Animal Resource Center in Transborder Medical Research Center, Faculty of Medicine, University of Tsukuba, 1-1-1 Tennodai, Tsukuba 305-8575, Japan.ORCID 0000-0002-8540-7760
Michito HamadaLaboratory Animal Resource Center in Transborder Medical Research Center, Faculty of Medicine, University of Tsukuba, 1-1-1 Tennodai, Tsukuba 305-8575, Japan.ORCID 0000-0002-4737-1007
University of Tsukuba · JP

Funding

Princess Takamatsu Cancer Research Fund 15-242724the Ministry of Education and Sports of Japan and the Ministry of Education JSPS 23118504the Ministry of Education and Sports of Japan and the Ministry of Education JSPS 25860205the Ministry of Education and Sports of Japan and the Ministry of Education JSPS 26221004the Ministry of Education and Sports of Japan and the Ministry of Education JSPS 16K 18398the Ministry of Education and Sports of Japan and the Ministry of Education JSPS 19H 00966the Ministry of Education and Sports of Japan and the Ministry of Education JSPS　19K 07499
6 · The paper itself

Abstract

MAFB is a basic leucine zipper (bZIP) transcription factor specifically expressed in macrophages. We have previously identified MAFB as a candidate marker for tumor-associated macrophages (TAMs) in human and mouse models. Here, we analyzed single-cell sequencing data of patients with lung adenocarcinoma obtained from the GEO database (GSE131907). Analyzed data showed that general macrophage marker CD68 and macrophage scavenger receptor 1 (CD204) were expressed in TAM and lung tissue macrophage clusters, while transcription factor MAFB was expressed specifically in TAM clusters. Clinical records of 120 patients with lung adenocarcinoma stage I (

Indexed as

Adenocarcinoma of LungLung NeoplasmsAnimalsBiomarkersHumansMacrophagesMafB Transcription FactorMicePrognosisBiomarkersMAFB protein, humanMafb protein, mouseMafB Transcription Factorbiomarkercancer prognosiscancer severityMAFBtumor-associated macrophages

Identifiers

PMID36077342
PMCPMC9456510
OpenAlexW4294151727

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.