Evidence map›Paper›PMID 36077336›Full record

ReviewInternational journal of molecular sciences2022

Matrix Vesicle-Mediated Mineralization and Osteocytic Regulation of Bone Mineralization.

Tomoka Hasegawa, Hiromi Hongo, Tomomaya Yamamoto, Miki Abe, Hirona Yoshino, Mai Haraguchi-Kitakamae, Hotaka Ishizu, Tomohiro Shimizu, Norimasa Iwasaki, Norio Amizuka

Open access · goldAbstract readReview
In one paragraph

Review in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
45citing papers in PubMed, 1 pooled it
10.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

45 citing papers in PubMed, 1 synthesis or guideline pooled it, 80 citations in OpenAlex.

  1. The Effect of Proton Pump Inhibitors on Bone MineralisationSultan Qaboos University medical journal · 2025
    Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Tomoka HasegawaDevelopmental Biology of Hard Tissue, Graduate School of Dental Medicine, Faculty of Dental Medicine, Hokkaido University, Sapporo 060-8586, Japan.ORCID 0000-0003-0309-6637
Hiromi HongoDevelopmental Biology of Hard Tissue, Graduate School of Dental Medicine, Faculty of Dental Medicine, Hokkaido University, Sapporo 060-8586, Japan.
Tomomaya YamamotoDevelopmental Biology of Hard Tissue, Graduate School of Dental Medicine, Faculty of Dental Medicine, Hokkaido University, Sapporo 060-8586, Japan.
Miki AbeDevelopmental Biology of Hard Tissue, Graduate School of Dental Medicine, Faculty of Dental Medicine, Hokkaido University, Sapporo 060-8586, Japan.
Hirona YoshinoDevelopmental Biology of Hard Tissue, Graduate School of Dental Medicine, Faculty of Dental Medicine, Hokkaido University, Sapporo 060-8586, Japan.
Mai Haraguchi-KitakamaeDevelopmental Biology of Hard Tissue, Graduate School of Dental Medicine, Faculty of Dental Medicine, Hokkaido University, Sapporo 060-8586, Japan.
Hotaka IshizuDevelopmental Biology of Hard Tissue, Graduate School of Dental Medicine, Faculty of Dental Medicine, Hokkaido University, Sapporo 060-8586, Japan.
Tomohiro ShimizuOrthopedic Surgery, Faculty of Medicine, Hokkaido University, Sapporo 060-8638, Japan.
Norimasa IwasakiOrthopedic Surgery, Faculty of Medicine, Hokkaido University, Sapporo 060-8638, Japan.ORCID 0000-0002-5496-4046
Norio AmizukaDevelopmental Biology of Hard Tissue, Graduate School of Dental Medicine, Faculty of Dental Medicine, Hokkaido University, Sapporo 060-8586, Japan.
Hokkaido University · JPTohoku University · JP

Funding

Japan Society for the Promotion of Science 21H03103Japan Society for the Promotion of Science 21K16928Japan Society for the Promotion of Science 22K09911Uehara Memorial Foundation 202110102
6 · The paper itself

Abstract

Bone mineralization entails two mineralization phases: primary and secondary mineralization. Primary mineralization is achieved when matrix vesicles are secreted by osteoblasts, and thereafter, bone mineral density gradually increases during secondary mineralization. Nearby extracellular phosphate ions (PO

Indexed as

Calcification, PhysiologicOsteocytesBone MatrixCollagenExtracellular MatrixOsteoblastsCollagenbone mineralizationmatrix vesicleosteoblastosteocytePhex/SIBLING

Identifiers

PMID36077336
PMCPMC9456179
OpenAlexW4294151928

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.