ReviewInternational journal of molecular sciences2022
Microbial Lipases and Their Potential in the Production of Pharmaceutical Building Blocks.
Review in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 53 citations in OpenAlex.
- Lipase ITB 2.1: a structure- and function-validated model for anti-obesity drug screening.Molecular diversity · 2026Article
- Microbial lipases: advances in metagenomics and artificial intelligence for enzyme discovery and engineering.Archives of microbiology · 2026Review
- Synthesis and characterization of ZrFeNanoscale advances · 2026Article
- Functional potential of gut microbiota inFrontiers in microbiology · 2026Article
- Chemical Modification ofInternational journal of molecular sciences · 2025Article
- Immobilized inclusion bodies of recombinant cold-adaptive lipase from Antarctic Pseudomonas sp. as catalysts.Applied microbiology and biotechnology · 2025Article
- Biosourcing and optimization of fungal lipase production from cheap agro waste via solid state fermentation.Scientific reports · 2025Article
- Cold-active lipase from Psychrobacter alimentarius ILMKVIT and its application in selective enrichment of ω-3 polyunsaturated fatty acids in flax seed oil.Bioprocess and biosystems engineering · 2025Article
- Use of genomics & proteomics in studying lipase producing microorganisms & its application.Food chemistry. Molecular sciences · 2024Article
- Recent insight into the advances and prospects of microbial lipases and their potential applications in industry.International microbiology : the official journal of the Spanish Society for Microbiology · 2024Review
- Enzymatic Kinetic Resolution of Racemic 1-(Isopropylamine)-3-phenoxy-2-propanol: A Building Block for β-Blockers.International journal of molecular sciences · 2024Article
- Biocatalysts Based on Immobilized Lipases for the Production of Fatty Acid Ethyl Esters: Enhancement of Activity through Ionic Additives and Ion Exchange Supports.Biotech (Basel (Switzerland)) · 2023Article
- Evaluation of Antibacterial Activity against Nosocomial Pathogens of an Enzymatically Derived α-Aminophosphonates Possessing Coumarin Scaffold.International journal of molecular sciences · 2023Article
- Lipase-Catalyzed Strategies for the Preparation of Enantiomeric THIQ and THMolecules (Basel, Switzerland) · 2023Review
- Short Peptides for Hydrolase Supramolecular Mimicry and Their Potential Applications.Gels (Basel, Switzerland) · 2023Review
- Trends in the Use of Lipases: A Systematic Review and Bibliometric Analysis.Foods (Basel, Switzerland) · 2023Review
- Engineering aRSC advances · 2023Article
- From Hamamelitannin Synthesis to the Study of Enzymatic Acylations of D-Hamamelose.Biomolecules · 2023Article
- Biocatalysis: An Eco-Friendly Scenario for the Manufacturing of APIs.International journal of molecular sciences · 2023Article
- Enzymatic Synthesis of Ascorbyl Palmitate in a Rotating Bed Reactor.Molecules (Basel, Switzerland) · 2023Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Processes involving lipases in obtaining active pharmaceutical ingredients (APIs) are crucial to increase the sustainability of the industry. Despite their lower production cost, microbial lipases are striking for their versatile catalyzing reactions beyond their physiological role. In the context of taking advantage of microbial lipases in reactions for the synthesis of API building blocks, this review focuses on: (i) the structural origins of the catalytic properties of microbial lipases, including the results of techniques such as single particle monitoring (SPT) and the description of its selectivity beyond the Kazlauskas rule as the "Mirror-Image Packing" or the "Key Region(s) rule influencing enantioselectivity" (KRIE); (ii) immobilization methods given the conferred operative advantages in industrial applications and their modulating capacity of lipase properties; and (iii) a comprehensive description of microbial lipases use as a conventional or promiscuous catalyst in key reactions in the organic synthesis (Knoevenagel condensation, Morita-Baylis-Hillman (MBH) reactions, Markovnikov additions, Baeyer-Villiger oxidation, racemization, among others). Finally, this review will also focus on a research perspective necessary to increase microbial lipases application development towards a greener industry.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.