Evidence map›Paper›PMID 36077306›Full record

ArticleInternational journal of molecular sciences2022

Targeting Lineage-Specific Transcription Factors and Cytokines of the Th17/Treg Axis by Novel 1,3,4-Oxadiazole Derivatives of Pyrrolo[3,4-

Marta Szandruk-Bender, Benita Wiatrak, Stanisław Dzimira, Anna Merwid-Ląd, Łukasz Szczukowski, Piotr Świątek, Adam Szeląg

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.9field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. 1,3,4-Oxadiazole Derivatives of Pyrrolo[3,4-Pharmaceuticals (Basel, Switzerland) · 2025
    Article
  3. Pyridazinone: Current Progress in Synthesis of its Derivatives and Biological Activity.Medicinal chemistry (Shariqah (United Arab Emirates)) · 2025
    Review
  4. Article
  5. Article
  6. Anti-Inflammatory and Antioxidant Pyrrolo[3,4-International journal of molecular sciences · 2024
    Article
  7. Amyloid, Crohn's disease, and Alzheimer's disease - are they linked?Frontiers in cellular and infection microbiology · 2024
    Review
  8. Molecules (Basel, Switzerland) · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Marta Szandruk-BenderDepartment of Pharmacology, Wroclaw Medical University, Mikulicza-Radeckiego 2, 50-345 Wrocław, Poland.ORCID 0000-0002-4571-9452
Benita WiatrakDepartment of Pharmacology, Wroclaw Medical University, Mikulicza-Radeckiego 2, 50-345 Wrocław, Poland.ORCID 0000-0002-1404-2274
Stanisław DzimiraDepartment of Pathology, Wroclaw University of Environmental and Life Sciences, Norwida 31, 50-375 Wrocław, Poland.ORCID 0000-0001-7203-2392
Anna Merwid-LądDepartment of Pharmacology, Wroclaw Medical University, Mikulicza-Radeckiego 2, 50-345 Wrocław, Poland.ORCID 0000-0002-4597-0241
Łukasz SzczukowskiDepartment of Medicinal Chemistry, Wroclaw Medical University, Borowska 211, 50-556 Wrocław, Poland.ORCID 0000-0002-9768-6269
Piotr ŚwiątekDepartment of Medicinal Chemistry, Wroclaw Medical University, Borowska 211, 50-556 Wrocław, Poland.ORCID 0000-0003-4613-025X
Adam SzelągDepartment of Pharmacology, Wroclaw Medical University, Mikulicza-Radeckiego 2, 50-345 Wrocław, Poland.ORCID 0000-0001-8104-5267
Wroclaw Medical University · PLWrocław University of Environmental and Life Sciences · PL

Funding

National Science Center Grant No. 2019/03/X/NZ7/0180
6 · The paper itself

Abstract

The pharmacotherapy of inflammatory bowel disease (IBD) is still not fully effective and safe. Attempts to search for new IBD drugs remain an incessant research aim. One of the novel approaches is targeting the developmental pathway molecules and effector cytokines of Th17/Treg axis. This study aimed to elucidate the impact of new pyrrolo[3,4-

Indexed as

ColitisInflammatory Bowel DiseasesAnimalsCytokinesDisease Models, AnimalInterleukin-17Interleukin-23Interleukin-6Nuclear Receptor Subfamily 1, Group F, Member 3OxadiazolesProstaglandins ERatsSTAT3 Transcription FactorTh17 CellsT-Lymphocytes, RegulatoryTrinitrobenzenesulfonic Acid1,3,4-oxadiazoleCytokinesInterleukin-17Interleukin-23Interleukin-6Nuclear Receptor Subfamily 1, Group F, Member 3OxadiazolesProstaglandins ESTAT3 Transcription FactorTrinitrobenzenesulfonic AcidTumor Necrosis Factor-alphaexperimental colitisFoxp3IL-23IL-6inflammatory bowel diseaseinflammatory mediatorspyrrolo[3,4-d]pyridazinoneRORγtTh17/Treg axistrinitrobenzenesulfonic acid

Identifiers

PMID36077306
PMCPMC9456461
OpenAlexW4294308424

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.