Evidence map›Paper›PMID 36077220›Full record

ArticleInternational journal of molecular sciences2022

Recurrent Translocations in Topoisomerase Inhibitor-Related Leukemia Are Determined by the Features of DNA Breaks Rather Than by the Proximity of the Translocating Genes.

Nikolai A Lomov, Vladimir S Viushkov, Sergey V Ulianov, Alexey A Gavrilov, Daniil A Alexeyevsky, Artem V Artemov, Sergey V Razin, Mikhail A Rubtsov

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.7field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 2 countries.

Nikolai A LomovDepartment of Molecular Biology, Faculty of Biology, Lomonosov Moscow State University, Moscow 119234, Russia.ORCID 0000-0003-2101-3479
Vladimir S ViushkovDepartment of Molecular Biology, Faculty of Biology, Lomonosov Moscow State University, Moscow 119234, Russia.
Sergey V UlianovDepartment of Molecular Biology, Faculty of Biology, Lomonosov Moscow State University, Moscow 119234, Russia.
Alexey A GavrilovInstitute of Gene Biology, Russian Academy of Sciences, Moscow 119334, Russia.
Daniil A AlexeyevskyA.N. Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, Moscow 119234, Russia.
Artem V ArtemovDepartment of Neuroimmunology, Center for Brain Research, Medical University of Vienna, 1090 Vienna, Austria.
Sergey V RazinDepartment of Molecular Biology, Faculty of Biology, Lomonosov Moscow State University, Moscow 119234, Russia.
Mikhail A RubtsovDepartment of Molecular Biology, Faculty of Biology, Lomonosov Moscow State University, Moscow 119234, Russia.ORCID 0000-0003-4947-1009
Lomonosov Moscow State University · RUInstitute of Gene Biology · RUMedical University of Vienna · ATSechenov University · RU

Funding

Ministry of Science and Higher Education of the Russian Federation 075-15-2021-1062Russian Foundation for Basic Research 19-04-00531_A
6 · The paper itself

Abstract

Topoisomerase inhibitors are widely used in cancer chemotherapy. However, one of the potential long-term adverse effects of such therapy is acute leukemia. A key feature of such therapy-induced acute myeloid leukemia (t-AML) is recurrent chromosomal translocations involving

Indexed as

Leukemia, Myeloid, AcuteTranslocation, GeneticDNADNA Breaks, Double-StrandedEtoposideHumansIn Situ Hybridization, FluorescenceTopoisomerase II InhibitorsDNAEtoposideTopoisomerase II InhibitorsAML1chromosomal translocationetoposideKMT2AMLLRUNX1t-AMLtherapy-related AMLtopoisomerase inhibitor-related leukemiatopoisomerase inhibitors

Identifiers

PMID36077220
PMCPMC9456246
OpenAlexW4293724636

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.