Evidence map›Paper›PMID 36077183›Full record

ArticleInternational journal of molecular sciences2022

Systemic and Renal Dynamics of Free Sulfhydryl Groups during Living Donor Kidney Transplantation.

Nora A Spraakman, Annemieke M Coester, Arno R Bourgonje, Vincent B Nieuwenhuijs, Jan-Stephan F Sanders, Henri G D Leuvenink, Harry van Goor, Gertrude J Nieuwenhuijs-Moeke

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.5field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Molecular Frontiers in Transplantation-Induced Ischemia-Reperfusion Injury.International journal of molecular sciences · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Nora A SpraakmanDepartment of Anesthesiology, University of Groningen, University Medical Centre Groningen, Hanzeplein 1, 9713 GZ Groningen, The Netherlands.ORCID 0000-0001-8614-589X
Annemieke M CoesterDepartment of Surgery, Amphia Hospital, Molengracht 21, 4818 CK Breda, The Netherlands.
Arno R BourgonjeDepartment of Gastroenterology and Hepatology, University of Groningen, University Medical Centre Groningen, Hanzeplein 1, 9713 GZ Groningen, The Netherlands.ORCID 0000-0001-5754-3821
Vincent B NieuwenhuijsDepartment of Surgery, Isala Zwolle, Dr. Van Heesweg 2, 8025 AB Zwolle, The Netherlands.
Jan-Stephan F SandersDepartment of Internal Medicine, Division of Nephrology, University Medical Center Groningen, Hanzeplein 1, 9713 GZ Groningen, The Netherlands.
Henri G D LeuveninkDepartment of Surgery, University of Groningen, University Medical Centre Groningen, Hanzeplein 1, 9713 GZ Groningen, The Netherlands.
Harry van GoorDepartment of Pathology and Medical Biology, University of Groningen, University Medical Centre Groningen, Hanzeplein 1, 9713 GZ Groningen, The Netherlands.ORCID 0000-0002-6670-1577
Gertrude J Nieuwenhuijs-MoekeDepartment of Anesthesiology, University of Groningen, University Medical Centre Groningen, Hanzeplein 1, 9713 GZ Groningen, The Netherlands.ORCID 0000-0001-9874-2632
University Medical Center Groningen · NLAmphia Ziekenhuis · NLIsala · NL

Funding

University Medical Centre Groningen, Groningen, the Netherlands 684000
6 · The paper itself

Abstract

During ischemia−reperfusion injury (IRI), reactive oxygen species are produced that can be scavenged by free sulfhydryl groups (R-SH, free thiols). In this study, we hypothesized that R-SH levels decrease as a consequence of renal IRI and that R-SH levels reflect post-transplant graft function. Systemic venous, arterial, renal venous, and urinary samples were collected in donors and recipients before, during, and after transplantation. R-SH was measured colorimetrically. Systemic arterial R-SH levels in recipients increased significantly up to 30 sec after reperfusion (p < 0.001). In contrast, renal venous R-SH levels significantly decreased at 5 and 10 min compared to 30 sec after reperfusion (both p < 0.001). This resulted in a significant decrease in delta R-SH (defined as the difference between renal venous and systemic arterial R-SH levels) till 30 sec after reperfusion (p < 0.001), indicating a net decrease in R-SH levels across the transplanted kidney. Overall, these results suggest trans-renal oxidative stress as a consequence of IRI during kidney transplantation, reflected by systemic and renal changes in R-SH levels in transplant recipients.

Indexed as

Kidney TransplantationReperfusion InjuryHumansKidneyLiving DonorsSulfhydryl CompoundsSulfhydryl Compoundsfree thiolsischemia–reperfusion injurykidney transplantationoxidative stressredox

Identifiers

PMID36077183
PMCPMC9455962
OpenAlexW4293724272

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.