Evidence map›Paper›PMID 36077132›Full record

ArticleInternational journal of molecular sciences2022

Balanced Free Essential Amino Acids and Resistance Exercise Training Synergistically Improve Dexamethasone-Induced Impairments in Muscle Strength, Endurance, and Insulin Sensitivity in Mice.

Jiwoong Jang, Jin-Ho Koh, Yeongmin Kim, Hee-Joo Kim, Sanghee Park, Yewon Chang, Jiyeon Jung, Robert R Wolfe, Il-Young Kim

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.4field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 14 citations in OpenAlex.

  1. Review
  2. Article
  3. CSE/HJournal of cachexia, sarcopenia and muscle · 2025
    Article
  4. Review
  5. Article
  6. Review
  7. Amino Acids in Health and Disease: The Good, the Bad, and the Ugly.International journal of molecular sciences · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 2 countries.

Jiwoong JangKorea Mouse Metabolic Phenotyping Center, Lee Gil Ya Cancer and Diabetes Institute, Gachon University, Incheon 21999, Korea.
Jin-Ho KohDepartment of Molecular Medicine, College of Medicine, Gachon University, Incheon 21565, Korea.
Yeongmin KimDepartment of Health Sciences and Technology, GAIHST, Gachon University, Incheon 21999, Korea.
Hee-Joo KimDepartment of Health Sciences and Technology, GAIHST, Gachon University, Incheon 21999, Korea.
Sanghee ParkDepartment of Internal Medicine, Gil Medical Center, Gachon University, Incheon 21565, Korea.ORCID 0000-0003-1632-3448
Yewon ChangDepartment of Health Sciences and Technology, GAIHST, Gachon University, Incheon 21999, Korea.ORCID 0000-0001-7976-0894
Jiyeon JungDepartment of Health Sciences and Technology, GAIHST, Gachon University, Incheon 21999, Korea.
Robert R WolfeDepartment of Geriatrics, Center for Translational Research in Aging and Longevity, Donald W. Reynolds Institute on Aging, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA.
Il-Young KimKorea Mouse Metabolic Phenotyping Center, Lee Gil Ya Cancer and Diabetes Institute, Gachon University, Incheon 21999, Korea.ORCID 0000-0002-6314-2415
Gachon University · KRInstitute on Aging · US

Funding

Ministry of Science ICT and Future Planning 2020R1F1A106680913National Research Foundation of Korea 2021R1A2C3005801
6 · The paper itself

Abstract

Our previous study shows that an essential amino acid (EAA)-enriched diet attenuates dexamethasone (DEX)-induced declines in muscle mass and strength, as well as insulin sensitivity, but does not affect endurance. In the present study, we hypothesized that the beneficial effects will be synergized by adding resistance exercise training (RET) to EAA, and diet-free EAA would improve endurance. To test hypotheses, mice were randomized into the following four groups: control, EAA, RET, and EAA+RET. All mice except the control were subjected to DEX treatment. We evaluated the cumulative rate of myofibrillar protein synthesis (MPS) using

Indexed as

Insulin ResistanceResistance TrainingAmino Acids, EssentialAnimalsDexamethasoneGlucoseHumansMiceMuscle, SkeletalMuscle StrengthAmino Acids, EssentialDexamethasoneGlucosedexamethasoneessential amino acidsglucose metabolic fluxmitochondrial biogenesismuscle atrophyneuromuscular junction stabilityphysical performanceprotein turnoverresistance exercise training

Identifiers

PMID36077132
PMCPMC9456044
OpenAlexW4293537881

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.