Evidence map›Paper›PMID 36077087›Full record

ArticleInternational journal of molecular sciences2022

Embryonic Hyperglycemia Delays the Development of Retinal Synapses in a Zebrafish Model.

Abhishek P Shrestha, Ambalavanan Saravanakumar, Bridget Konadu, Saivikram Madireddy, Yann Gibert, Thirumalini Vaithianathan

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.0field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 12 citations in OpenAlex.

  1. Molecules (Basel, Switzerland) · 2026
    Article
  2. Article
  3. Article
  4. Tauroursodeoxycholic Acid Alleviates Endoplasmic Reticulum Stress-Mediated Visual Deficits in Diabetic tie2-TNF Transgenic Mice via TGR5 Signaling.Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Abhishek P ShresthaDepartment of Pharmacology, Addiction Science, and Toxicology, College of Medicine, University of Tennessee Health Science Center, Memphis, TN 38163, USA.
Ambalavanan SaravanakumarDepartment of Pharmacology, Addiction Science, and Toxicology, College of Medicine, University of Tennessee Health Science Center, Memphis, TN 38163, USA.
Bridget KonaduDepartment of Cell and Molecular Biology, University of Mississippi Medical Center, Jackson, MS 39216, USA.
Saivikram MadireddyDepartment of Pharmacology, Addiction Science, and Toxicology, College of Medicine, University of Tennessee Health Science Center, Memphis, TN 38163, USA.
Yann GibertDepartment of Cell and Molecular Biology, University of Mississippi Medical Center, Jackson, MS 39216, USA.ORCID 0000-0001-8208-7223
Thirumalini VaithianathanDepartment of Pharmacology, Addiction Science, and Toxicology, College of Medicine, University of Tennessee Health Science Center, Memphis, TN 38163, USA.ORCID 0000-0002-7686-5284
University of Tennessee Health Science Center · USUniversity of Mississippi Medical Center · USRhodes College · US

Funding

The role of leptin in autoimmune-associated hypertensionP20GM104357 · NIGMS · UNIVERSITY OF MISSISSIPPI MED CTR · PI TAYLOR, ERIN BASSFORD · 2013 to 2022
$23.4M
Dynamics of calcium signals control neurotransmitter release in retinal ribbon synapses.R01EY030863 · NEI · UNIVERSITY OF TENNESSEE HEALTH SCI CTR · PI VAITHIANATHAN, THIRUMALINI · 2021 to 2025
$2.3M
Mechanisms responsible for tooth morphogenesis in vertebratesR01DE029803 · NIDCR · UNIVERSITY OF MISSISSIPPI MED CTR · PI GIBERT, YANN · 2021 to 2025
$1.8M
NEI NIH HHS R01 EY030863NIDCR NIH HHS R01 DE029803NIGMS NIH HHS P20 GM104357NIH HHS P20GM104357NIH HHS R01DE029803NIH HHS R01EY030863UTHSC OFFICE OF RESEARCH New grant support
6 · The paper itself

Abstract

Embryonic hyperglycemia negatively impacts retinal development, leading to abnormal visual behavior, altered timing of retinal progenitor differentiation, decreased numbers of retinal ganglion cells and Müller glia, and vascular leakage. Because synaptic disorganization is a prominent feature of many neurological diseases, the goal of the current work was to study the potential impact of hyperglycemia on retinal ribbon synapses during embryonic development. Our approach utilized reverse transcription quantitative PCR (RT-qPCR) and immunofluorescence labeling to compare the transcription of synaptic proteins and their localization in hyperglycemic zebrafish embryos, respectively. Our data revealed that the maturity of synaptic ribbons was compromised in hyperglycemic zebrafish larvae, where altered

Indexed as

HyperglycemiaZebrafishAnimalsRetinaSynapsesZebrafish ProteinsZebrafish Proteinshyperglycemiaretinal developmentribbon synapseribeye proteinsynaptic proteinszebrafish (Danio rerio) model

Identifiers

PMID36077087
PMCPMC9456524
OpenAlexW4293538578

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.