Evidence map›Paper›PMID 36077072›Full record

ArticleInternational journal of molecular sciences2022

Compound C Inhibits Renca Renal Epithelial Carcinoma Growth in Syngeneic Mouse Models by Blocking Cell Cycle Progression, Adhesion and Invasion.

Myungyeon Lee, Na Yeon Ham, Chi Yeon Hwang, Jiwon Jang, Boram Lee, Joo-Won Jeong, Insug Kang, Eui-Ju Yeo

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.0field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 12 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Myungyeon LeeDepartment of Medicine, Gachon University School of Medicine, Incheon 21999, Korea.
Na Yeon HamDepartment of Biochemistry, College of Medicine, Gachon University, Incheon 21999, Korea.
Chi Yeon HwangDepartment of Biomedical Sciences, Graduate School, Kyung Hee University, Seoul 02447, Korea.
Jiwon JangDepartment of Biomedical Sciences, Graduate School, Kyung Hee University, Seoul 02447, Korea.
Boram LeeDepartment of Biochemistry, College of Medicine, Gachon University, Incheon 21999, Korea.
Joo-Won JeongDepartment of Anatomy and Neurobiology, School of Medicine, Kyung Hee University, Seoul 02447, Korea.
Insug KangDepartment of Biochemistry and Molecular Biology, Biomedical Science Institute, School of Medicine, Kyung Hee University, Seoul 02447, Korea.ORCID 0000-0001-7117-1008
Eui-Ju YeoDepartment of Biochemistry, College of Medicine, Gachon University, Incheon 21999, Korea.
Gachon University · KRKyung Hee University · KR

Funding

National Research Foundation of Korea 2018R1A6A1A03025124National Research Foundation of Korea 2020R1F1A1072202
6 · The paper itself

Abstract

Compound C (CompC), an inhibitor of AMP-activated protein kinase, reduces the viability of various renal carcinoma cells. The molecular mechanism underlying anti-proliferative effect was investigated by flow cytometry and western blot analysis in Renca cells. Its effect on the growth of Renca xenografts was also examined in a syngeneic BALB/c mouse model. Subsequent results demonstrated that CompC reduced platelet-derived growth factor receptor signaling pathways and increased ERK1/2 activation as well as reactive oxygen species (ROS) production. CompC also increased the level of active Wee1 tyrosine kinase (P-Ser

Indexed as

Carcinoma, Renal CellKidney NeoplasmsAnimalsCell DivisionDisease Models, AnimalHistonesHumansMiceMice, Inbred BALB CReactive Oxygen SpeciesHistonesReactive Oxygen SpeciesBALB/cCompound CG2/M cell cycle arrestrenal cancer cellsRenca cellsROS

Identifiers

PMID36077072
PMCPMC9456023
OpenAlexW4293539135

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.