Evidence map›Paper›PMID 36077014›Full record

ArticleInternational journal of molecular sciences2022

Dock10 Regulates Cardiac Function under Neurohormonal Stress.

Liad Segal, Sharon Etzion, Sigal Elyagon, Moran Shahar, Hadar Klapper-Goldstein, Aviva Levitas, Michael S Kapiloff, Ruti Parvari, Yoram Etzion

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.0field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Liad SegalDepartment of Physiology and Cell Biology, Ben-Gurion University of the Negev, Beer-Sheva 8410501, Israel.
Sharon EtzionRegenerative Medicine and Stem Cell (RMSC) Research Center, Ben-Gurion University of the Negev, Beer-Sheva 8410501, Israel.
Sigal ElyagonDepartment of Physiology and Cell Biology, Ben-Gurion University of the Negev, Beer-Sheva 8410501, Israel.
Moran ShaharDepartment of Physiology and Cell Biology, Ben-Gurion University of the Negev, Beer-Sheva 8410501, Israel.
Hadar Klapper-GoldsteinDepartment of Physiology and Cell Biology, Ben-Gurion University of the Negev, Beer-Sheva 8410501, Israel.ORCID 0000-0002-8783-9364
Aviva LevitasPediatric Cardiology Department, Soroka University Medical Center, Beer-Sheva 8410501, Israel.
Michael S KapiloffDepartments of Ophthalmology and Medicine (Cardiovascular Medicine), Stanford Cardiovascular Institute, Stanford University, Palo Alto 94304-1209, CA, USA.
Ruti ParvariThe Shraga Segal Department of Microbiology, Immunology and Genetics, Ben-Gurion University of the Negev, Beer-Sheva 8410501, Israel.ORCID 0000-0002-0656-3096
Yoram EtzionDepartment of Physiology and Cell Biology, Ben-Gurion University of the Negev, Beer-Sheva 8410501, Israel.ORCID 0000-0002-9930-1035
Ben-Gurion University of the Negev · ILCardiovascular Institute of the South · USSoroka Medical Center · IL

Funding

Stanford Vision Research CoreP30EY026877 · NEI · STANFORD UNIVERSITY · PI Jeffrey L Goldberg · 2017 to 2026
$8.0M
Calcineurin compartmentation and regulation of pathological cardiac remodelingR01HL158052 · NHLBI · STANFORD UNIVERSITY · PI KAPILOFF, MICHAEL SETH · 2021 to 2024
$2.1M
Gassner Fund for Medical Research No NumberNational Institute for Biotechnology in the Negev No NumberNational Institute of Health R01HL158052NEI NIH HHS P30 EY026877NHLBI NIH HHS R01 HL158052
6 · The paper itself

Abstract

Dedicator of cytokinesis 10 (Dock10) is a guanine nucleotide exchange factor for Cdc42 and Rac1 that regulates the JNK (c-Jun N-terminal kinase) and p38 MAPK (mitogen-activated protein kinase) signaling cascades. In this study, we characterized the roles of Dock10 in the myocardium. In vitro: we ablated Dock10 in neonatal mouse floxed

Indexed as

Myocytes, Cardiacp38 Mitogen-Activated Protein KinasesAngiotensin IIAnimalsCardiomegalyGuanine Nucleotide Exchange FactorsJNK Mitogen-Activated Protein KinasesMiceMyocardiumSignal TransductionAngiotensin IIDOCK10 protein, mouseGuanine Nucleotide Exchange FactorsJNK Mitogen-Activated Protein Kinasesp38 Mitogen-Activated Protein KinasesCdc42MAPK signalingpathological cardiac hypertrophyRac1Rho GTPases

Identifiers

PMID36077014
PMCPMC9455810
OpenAlexW4293104085

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.