Evidence map›Paper›PMID 36076995›Full record

ArticleInternational journal of molecular sciences2022

Mitochonic Acid 5 Improves Duchenne Muscular Dystrophy and Parkinson's Disease Model of

Xintong Wu, Satoi Nagasawa, Kasumi Muto, Maiko Ueda, Chitose Suzuki, Takaaki Abe, Atsushi Higashitani

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.7field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Article
  3. Increased mitochondrial CaFASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2023
    Article
  4. Biomolecules · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Xintong WuGraduate School of Life Sciences, Tohoku University, Sendai 980-8577, Japan.ORCID 0000-0002-7635-6471
Satoi NagasawaGraduate School of Life Sciences, Tohoku University, Sendai 980-8577, Japan.
Kasumi MutoGraduate School of Life Sciences, Tohoku University, Sendai 980-8577, Japan.
Maiko UedaBiomedical Research Core, Tohoku University Graduate School of Medicine, Sendai 980-0872, Japan.
Chitose SuzukiDepartment of Clinical Biology and Hormonal Regulation, Tohoku University Graduate School of Medicine, Sendai 980-0872, Japan.
Takaaki AbeDepartment of Clinical Biology and Hormonal Regulation, Tohoku University Graduate School of Medicine, Sendai 980-0872, Japan.
Atsushi HigashitaniGraduate School of Life Sciences, Tohoku University, Sendai 980-8577, Japan.ORCID 0000-0001-6920-0594
Tohoku University · JP

Funding

Enhancing and expanding the CGC Strain CollectionP40OD010440 · OD · UNIVERSITY OF MINNESOTA · PI Ann E. Rougvie · 2012 to 2026
$7.5M
Japan Agency for Medical Research and Development AMED-CREST 16814305Japan Agency for Medical Research and Development JP21zf0127001NIH HHS P40 OD010440
6 · The paper itself

Abstract

Mitochonic Acid 5 (MA-5) enhances mitochondrial ATP production, restores fibroblasts from mitochondrial disease patients and extends the lifespan of the disease model "Mitomouse". Additionally, MA-5 interacts with mitofilin and modulates the mitochondrial inner membrane organizing system (MINOS) in mammalian cultured cells. Here, we used the nematode

Indexed as

Muscular Dystrophy, DuchenneParkinson DiseaseAdenosine TriphosphateAnimalsCaenorhabditis elegansHumansIndoleacetic AcidsMammalsPhenylbutyratesRotenone4-(2,4-difluorophenyl)-2-(1H-indol-3-yl)-4-oxobutanoic acidAdenosine TriphosphateIndoleacetic AcidsPhenylbutyratesRotenoneMA-5mitochondrial calciummitochondrial fragmentationmuscular dystrophyParkinson’s diseaserotenone

Identifiers

PMID36076995
PMCPMC9455831
OpenAlexW4292999063

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.