Evidence map›Paper›PMID 36076937›Full record

ArticleInternational journal of molecular sciences2022

A Curcumin-BODIPY Dyad and Its Silica Hybrid as NIR Bioimaging Probes.

Chiara Maria Antonietta Gangemi, Tania Maria Grazia Salerno, Anna Barattucci, Fabio Cucinotta, Paola Bonaccorsi, Giovanna Calabrese, Paola Poma, Maria Giovanna Rizzo, Sebastiano Campagna, Fausto Puntoriero

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 69% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Bioimaging and Sensing Properties of Curcumin and Derivatives.International journal of molecular sciences · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

Chiara Maria Antonietta GangemiDipartimento di Scienze Chimiche Biologiche Farmaceutiche ed Ambientali (CHIBIOFARAM), Università degli Studi di Messina, 98166 Messina, Italy.ORCID 0000-0002-6978-1779
Tania Maria Grazia SalernoDipartimento di Scienze Chimiche Biologiche Farmaceutiche ed Ambientali (CHIBIOFARAM), Università degli Studi di Messina, 98166 Messina, Italy.
Anna BarattucciDipartimento di Scienze Chimiche Biologiche Farmaceutiche ed Ambientali (CHIBIOFARAM), Università degli Studi di Messina, 98166 Messina, Italy.ORCID 0000-0002-2415-5483
Fabio CucinottaSchool of Natural and Environmental Sciences, Newcastle University, Newcastle upon Tyne NE1 7RU, UK.
Paola BonaccorsiDipartimento di Scienze Chimiche Biologiche Farmaceutiche ed Ambientali (CHIBIOFARAM), Università degli Studi di Messina, 98166 Messina, Italy.ORCID 0000-0002-7914-5653
Giovanna CalabreseDipartimento di Scienze Chimiche Biologiche Farmaceutiche ed Ambientali (CHIBIOFARAM), Università degli Studi di Messina, 98166 Messina, Italy.ORCID 0000-0003-1937-5403
Paola PomaDipartimento di Scienze e Tecnologie Biologiche, Chimiche e Farmaceutiche (STEBICEF), Università degli Studi di Palermo, 90128 Palermo, Italy.
Maria Giovanna RizzoDipartimento di Scienze Chimiche Biologiche Farmaceutiche ed Ambientali (CHIBIOFARAM), Università degli Studi di Messina, 98166 Messina, Italy.
Sebastiano CampagnaDipartimento di Scienze Chimiche Biologiche Farmaceutiche ed Ambientali (CHIBIOFARAM), Università degli Studi di Messina, 98166 Messina, Italy.ORCID 0000-0003-3385-2528
Fausto PuntorieroDipartimento di Scienze Chimiche Biologiche Farmaceutiche ed Ambientali (CHIBIOFARAM), Università degli Studi di Messina, 98166 Messina, Italy.ORCID 0000-0001-8579-859X
University of Messina · ITNewcastle University · GBUniversity of Palermo · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In this paper we describe the synthesis of a novel bichromophoric system in which an efficient photoinduced intercomponent energy transfer process is active. The dyad consists of one subunit of curcumin and one of BODIPY and is able to emit in the far-red region, offering a large Stokes shift, capable of limiting light scattering processes for applications in microscopy. The system has been encapsulated in MCM-41 nanoparticles with dimensions between 50 and 80 nm. Both the molecular dyad and individual subunits were tested with different cell lines to study their effective applicability in bioimaging. MCM-41 nanoparticles showed no reduction in cell viability, indicating their biocompatibility and bio-inertness and making them capable of delivering organic molecules even in aqueous-based formulations, avoiding the toxicity of organic solvents. Encapsulation in the porous silica structure directed the location of the bichromophoric system within cytoplasm, while the dyad alone stains the nucleus of the hFOB cell line.

Indexed as

CurcuminNanoparticlesBoron CompoundsSilicon Dioxide4,4-difluoro-4-bora-3a,4a-diaza-s-indaceneBoron CompoundsCurcuminSilicon Dioxidebichromophoric dyadbioimagingBODIPYcurcuminluminescenceNIR probes

Identifiers

PMID36076937
PMCPMC9455722
OpenAlexW4293215161

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.