Evidence map›Paper›PMID 36076933›Full record

ArticleInternational journal of molecular sciences2022

Peptidylarginine Deiminase 2 Gene Polymorphisms in Subjects with Periodontitis Predispose to Rheumatoid Arthritis.

Laura Massarenti, Christian Enevold, Dres Damgaard, Peter Riis Hansen, Morten Frisch, Niels Ødum, Søren Jacobsen, Claus Henrik Nielsen

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
1.0field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it, 6 citations in OpenAlex.

  1. Pooled it
  2. Periodontitis Salivary Microbiota Exacerbates Murine Rheumatoid Arthritis via Gut Dysbiosis and Immune Dysregulation.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2025
    Article
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Laura MassarentiInstitute for Inflammation Research, Center for Rheumatology and Spine Disease, Section 7521, Copenhagen University Hospital Rigshospitalet, 2200 Copenhagen, Denmark.
Christian EnevoldInstitute for Inflammation Research, Center for Rheumatology and Spine Disease, Section 7521, Copenhagen University Hospital Rigshospitalet, 2200 Copenhagen, Denmark.
Dres DamgaardInstitute for Inflammation Research, Center for Rheumatology and Spine Disease, Section 7521, Copenhagen University Hospital Rigshospitalet, 2200 Copenhagen, Denmark.
Peter Riis HansenDepartment of Cardiology, Herlev-Gentofte Hospital, 2900 Hellerup, Denmark.ORCID 0000-0002-9056-535X
Morten FrischDepartment of Epidemiology Research, Statens Serum Institut, 2300 Copenhagen, Denmark.ORCID 0000-0002-3864-8860
Niels ØdumLEO Foundation Skin Immunology Research Center, Department of Immunology and Microbiology, University of Copenhagen, 2200 Copenhagen, Denmark.ORCID 0000-0003-3135-5624
Søren JacobsenDepartment of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, 2200 Copenhagen, Denmark.ORCID 0000-0002-5654-4993
Claus Henrik NielsenInstitute for Inflammation Research, Center for Rheumatology and Spine Disease, Section 7521, Copenhagen University Hospital Rigshospitalet, 2200 Copenhagen, Denmark.ORCID 0000-0001-7543-9016
University of Copenhagen · DKCopenhagen University Hospital · DKStatens Serum Institut · DK

Funding

Independent Research Fund DFF - 7016-00233The Danish Rheumatism Association A3865
6 · The paper itself

Abstract

Epidemiologic studies have shown associations between periodontitis and rheumatoid arthritis (RA), but a causal relationship has not been established. Citrullination of gingival proteins by human peptidylarginine deiminases (PADs) or PAD from

Indexed as

Arthritis, RheumatoidPeriodontitisProtein-Arginine DeiminasesAnti-Citrullinated Protein AntibodiesAutoantibodiesHumansHydrolasesPolymorphism, Single NucleotideAnti-Citrullinated Protein AntibodiesAutoantibodiesHydrolasesProtein-Arginine Deiminasesanti-citrullinated protein antibodies (ACPAs)peptidylarginine deiminasesperiodontitisrheumatoid arthritissingle nucleotide polymorphism

Identifiers

PMID36076933
PMCPMC9455246
OpenAlexW4293020286

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.