Evidence map›Paper›PMID 36076920›Full record

ArticleInternational journal of molecular sciences2022

Low-Dose Near-Infrared Light-Activated Mitochondria-Targeting Photosensitizers for PDT Cancer Therapy.

Wenyu Wu Klingler, Nadine Giger, Lukas Schneider, Vipin Babu, Christiane König, Patrick Spielmann, Roland H Wenger, Stefano Ferrari, Bernhard Spingler

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Wenyu Wu KlinglerDepartment of Chemistry, University of Zurich, Winterthurerstrasse 190, 8057 Zurich, Switzerland.ORCID 0000-0001-9365-684X
Nadine GigerDepartment of Chemistry, University of Zurich, Winterthurerstrasse 190, 8057 Zurich, Switzerland.
Lukas SchneiderDepartment of Chemistry, University of Zurich, Winterthurerstrasse 190, 8057 Zurich, Switzerland.ORCID 0000-0003-0052-4560
Vipin BabuDepartment of Chemistry, University of Zurich, Winterthurerstrasse 190, 8057 Zurich, Switzerland.ORCID 0000-0002-0001-8783
Christiane KönigInstitute of Molecular Cancer Research, University of Zurich, Winterthurerstrasse 190, 8057 Zurich, Switzerland.
Patrick SpielmannInstitute of Physiology, University of Zurich, Winterthurerstrasse 190, 8057 Zurich, Switzerland.ORCID 0000-0001-7056-0351
Roland H WengerInstitute of Physiology, University of Zurich, Winterthurerstrasse 190, 8057 Zurich, Switzerland.ORCID 0000-0001-7592-4839
Stefano FerrariInstitute of Molecular Cancer Research, University of Zurich, Winterthurerstrasse 190, 8057 Zurich, Switzerland.
Bernhard SpinglerDepartment of Chemistry, University of Zurich, Winterthurerstrasse 190, 8057 Zurich, Switzerland.ORCID 0000-0003-3402-2016

Funding

Novartis Foundation #18B085Swiss National Science Foundation 205321_159976Swiss National Science Foundation 206021_164018
6 · The paper itself

Abstract

Phthalocyanines (Pcs) are promising candidates for photodynamic therapy (PDT) due to their absorption in the phototherapeutic window. However, the highly aromatic Pc core leads to undesired aggregation and decreased reactive oxygen species (ROS) production. Therefore, short PEG chain functionalized A

Indexed as

Ovarian NeoplasmsPhotochemotherapyCell Line, TumorFemaleHumansMitochondriaPhotosensitizing AgentsPhotosensitizing Agentscancer treatmentcisplatincrystal structurecytotoxicityphotocytotoxicityphotodynamic therapy (PDT)phototoxic index (p.i.)phthalocyanine

Identifiers

PMID36076920
PMCPMC9455738

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.