Evidence map›Paper›PMID 36076291›Full record

ArticleRespiratory research2022

Wood smoke exposure affects lung aging, quality of life, and all-cause mortality in New Mexican smokers.

Shuguang Leng, Maria A Picchi, Paula M Meek, Menghui Jiang, Samuel H Bayliss, Ting Zhai, Ruslan I Bayliyev, Yohannes Tesfaigzi, Matthew J Campen, Huining Kang and 4 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Respiratory research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.2field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 15 citations in OpenAlex.

  1. Preclinical models of COPD: a state of the art review.The European respiratory journal · 2026
    Review
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  9. The Intersection of Socioeconomic and Environmental Factors in Aging: Insights from a Narrative Review.International journal of environmental research and public health · 2025
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 8 institutions in 1 country.

Shuguang LengDepartment of Internal Medicine, School of Medicine, University of New Mexico, Albuquerque, NM, 87131, USA. sleng@salud.unm.edu.
Maria A PicchiLung Cancer Program, Lovelace Biomedical Research Institute, Albuquerque, NM, 87108, USA.
Paula M MeekCollege of Nursing, University of Utah, Salt Lake City, UT, 84112, USA.
Menghui JiangDepartment of Internal Medicine, School of Medicine, University of New Mexico, Albuquerque, NM, 87131, USA.
Samuel H BaylissDepartment of Internal Medicine, School of Medicine, University of New Mexico, Albuquerque, NM, 87131, USA.
Ting ZhaiDepartment of Internal Medicine, School of Medicine, University of New Mexico, Albuquerque, NM, 87131, USA.
Ruslan I BayliyevDepartment of Internal Medicine, School of Medicine, University of New Mexico, Albuquerque, NM, 87131, USA.
Yohannes TesfaigziPulmonary and Critical Care Medicine Division, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 01255, USA.
Matthew J CampenCancer Control and Population Sciences, University of New Mexico Comprehensive Cancer Center, Albuquerque, NM, 87131, USA.
Huining KangDepartment of Internal Medicine, School of Medicine, University of New Mexico, Albuquerque, NM, 87131, USA.
Yiliang ZhuDepartment of Internal Medicine, School of Medicine, University of New Mexico, Albuquerque, NM, 87131, USA.
Qing LanDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, MD, USA.
Akshay SoodDepartment of Internal Medicine, School of Medicine, University of New Mexico, Albuquerque, NM, 87131, USA.
Steven A BelinskyCancer Control and Population Sciences, University of New Mexico Comprehensive Cancer Center, Albuquerque, NM, 87131, USA.
University of New Mexico · USLovelace Respiratory Research Institute · USNew Mexico Cancer Center · USBrigham and Women's Hospital · USHarvard University · USNational Institutes of Health · USUniversity of Utah · USUNM Comprehensive Cancer Center

Funding

WOMEN'S CANCERS RESEARCH PROGRAMP30CA118100 · NCI · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI Yolanda Sanchez · 2005 to 2026
$57.1M
Tracking and EvaluationU54GM104944 · NIGMS · UNIVERSITY OF NEVADA LAS VEGAS · PI MARCHAND, GWEN · 2013 to 2023
$39.6M
Factors for Epigenetic Silencing of Lung Cancer GenesR01CA097356 · NCI · LOVELACE BIOMEDICAL & ENVIRONMENTAL RESEARCH INSTITUTE · PI BELINSKY, STEVEN A · 2004 to 2014
$6.3M
NCI NIH HHS P30 CA118100NCI NIH HHS R01 CA097356NIGMS NIH HHS U54 GM104944
6 · The paper itself

Abstract

backgroundThe role of wood smoke (WS) exposure in the etiology of chronic obstructive pulmonary disease (COPD), lung cancer (LC), and mortality remains elusive in adults from countries with low ambient levels of combustion-emitted particulate matter. This study aims to delineate the impact of WS exposure on lung health and mortality in adults age 40 and older who ever smoked.

methodsWe assessed health impact of self-reported "ever WS exposure for over a year" in the Lovelace Smokers Cohort using both objective measures (i.e., lung function decline, LC incidence, and deaths) and two health related quality-of-life questionnaires (i.e., lung disease-specific St. George's Respiratory Questionnaire [SGRQ] and the generic 36-item short-form health survey).

resultsCompared to subjects without WS exposure, subjects with WS exposure had a more rapid decline of FEV1 (- 4.3 ml/s, P = 0.025) and FEV1/FVC ratio (- 0.093%, P = 0.015), but not of FVC (- 2.4 ml, P = 0.30). Age modified the impacts of WS exposure on lung function decline. WS exposure impaired all health domains with the increase in SGRQ scores exceeding the minimal clinically important difference. WS exposure increased hazard for incidence of LC and death of all-cause, cardiopulmonary diseases, and cancers by > 50% and shortened the lifespan by 3.5 year. We found no evidence for differential misclassification or confounding from socioeconomic status for the health effects of WS exposure.

conclusionsWe identified epidemiological evidence supporting WS exposure as an independent etiological factor for the development of COPD through accelerating lung function decline in an obstructive pattern. Time-to-event analyses of LC incidence and cancer-specific mortality provide human evidence supporting the carcinogenicity of WS exposure.

Indexed as

Pulmonary Disease, Chronic ObstructiveQuality of LifeAdultAgingHumansLungSmokeSmokersWoodSmokeHealth related quality-of-lifeLung cancerLung function declineMortalityWood smoke

Identifiers

PMID36076291
PMCPMC9454202
OpenAlexW4294943801

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.