ArticleJournal of ovarian research2022
Effects of vitrified cryopreservation duration on IVF and neonatal outcomes.
Article in Journal of ovarian research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 2 of them syntheses that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Optimal timing for frozen-thawed embryo transfer: evidence from a systematic review and meta-analysis.Frontiers in endocrinology · 2026Pooled it
- Impact of prolonged embryo storage on reproductive and neonatal outcomes: a systematic review and meta-analysis.Journal of assisted reproduction and genetics · 2024Pooled it
- Intrauterine infusion of autologous platelet rich plasma can be an efficient treatment for patients with unexplained recurrent implantation failure.Scientific reports · 2024Trial
- The effect of embryo vitrification duration on frozen-thawed transfer outcomes: the key moderating role of age-a retrospective cohort study of 13,054 cycles.Journal of assisted reproduction and genetics · 2026Article
- Effects of prolonged embryo cryopreservation after fertility treatment in Denmark.Reproduction & fertility · 2026Article
- Elevated Salivary Antioxidant Biomarkers are Favorable for Clinical Pregnancy in Women Undergoing IVF: A Prospective Cohort Study.Health science reports · 2026Article
- Does Prolonged Preservation of Blastocysts Affect the Implantation and Live Birth Rate? A Danish Nationwide Register-Based Study.Journal of clinical medicine · 2026Article
- Fertility preservation and subsequent reproductive outcomes in female pediatric patients with hematologic malignancies.Frontiers in endocrinology · 2026Review
- Impact of post-vitrification storage duration on clinical outcomes of frozen-thawed cleavage-stage embryos transfer: a propensity score-matched retrospective cohort study.Frontiers in endocrinology · 2026Article
- Maternal exposure to cyclophosphamide during prepubertal life does not affect the cryosusceptibility of in vitro derived mouse embryos.Reproduction & fertility · 2026Article
- Effect of cryopreservation duration on pregnancy outcomes in embryos: a systematic review and meta-analysis.Human reproduction open · 2026Review
- Impact of PGT Introduction on IVF Laboratory Workload: Lessons Learned from a Single-Center Experience of 5258 Biopsies over a 10-Year Period.Life (Basel, Switzerland) · 2025Article
- Comparison of oral dydrogesterone and vaginal progesterone for luteal phase support in natural and modified natural cycle frozen embryo transfers.Journal of ovarian research · 2025Article
- In Vıtro Productıon of Bovıne Blastocysts and Cryopreservatıon Technıques.Advances in experimental medicine and biology · 2025Review
- Advanced maternal age affects their frozen-thawed embryo susceptibility to high oxygen environment.Scientific reports · 2024Article
- Vitrification preservation of good-quality blastocysts for more than 5 years reduces implantation and live birth rates.Human reproduction (Oxford, England) · 2024Article
- Effects of Embryo Microbial Contamination on ART and Neonatal Outcomes.Infection and drug resistance · 2024Article
- Effect of post-vitrification cryopreservation duration on singleton birth-weight in frozen-thawed blastocysts transfer cycles.Frontiers in endocrinology · 2024Observational
- Storage duration of vitrified embryos does not affect pregnancy and neonatal outcomes after frozen-thawed embryo transfer.Frontiers in endocrinology · 2023Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
backgroundIn this study, we aimed to evaluate the impact of the duration of cryopreservation storage on embryo viability, implantation competence, pregnancy outcome and neonatal outcomes.
methodsWe retrospectively evaluated the outcomes of patients who underwent IVF with vitrified cryopreserved embryos between January 2004 and August 2019 by following the first frozen embryo transfer cycles within the study period. A total of 31,143 patients met the inclusion criteria and were grouped according to the embryo storage time as follows: Group 1 (n = 20,926),1-90 days; Group 2 (n = 6,472), 91-180 days; Group 3 (n = 2,237), 181-365 days; Group 4 (n = 746), 366-730 days; and Group 5 (n = 762), > 731 days.
resultsThe embryo survival rate decreased significantly with longer durations of cryopreservation. The highest and lowest survival rate was recorded in Group 1 and Group 5, respectively (34853/35338; 98.63% vs. 1281/1801; 71.13%; P < 0.01). The human chorionic gonadotropin (HCG) detection and clinical pregnancy rate was highest in Group 1 (57.85% and 55. 26%, respectively; P < 0.01). Short-term cryopreservation (≤ 3 months) is associated with higher rates of clinical pregnancy. There were no significant differences in neonatal birth weight, neonatal height and congenital anomalies among the groups (P > 0. 05).
conclusionThe prolonged storage time of vitrified embryos negatively affected survival rate and clinical pregnancy rate. It did not have a significant influence on neonatal health. This study provides new findings about the relationship between prolonged storage time of vitrified embryos and clinical outcomes and offers evidence for the safety of using long-stored embryos after vitrification.
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