Evidence map›Paper›PMID 36076188›Full record

ArticleBMC genomics2022

Natural variation in the maternal and zygotic mRNA complements of the early embryo in Drosophila melanogaster.

Anna A Feitzinger, Anthony Le, Ammon Thompson, Mehnoor Haseeb, Mohan Koumar Murugesan, Austin M Tang, Susan E Lott

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC genomics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.6field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Anna A FeitzingerDepartment of Evolution and Ecology, University of California, Davis, CA, 95616, USA. afeitzinger@ucdavis.edu.
Anthony LeDepartment of Evolution and Ecology, University of California, Davis, CA, 95616, USA.
Ammon ThompsonDepartment of Evolution and Ecology, University of California, Davis, CA, 95616, USA.
Mehnoor HaseebDepartment of Evolution and Ecology, University of California, Davis, CA, 95616, USA.
Mohan Koumar MurugesanDepartment of Evolution and Ecology, University of California, Davis, CA, 95616, USA.
Austin M TangDepartment of Evolution and Ecology, University of California, Davis, CA, 95616, USA.
Susan E LottDepartment of Evolution and Ecology, University of California, Davis, CA, 95616, USA.
University of California, Davis · US

Funding

Evolution of the mRNA pool in Drosophila eggs and its effect on developmentR01GM111362 · NIGMS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI LOTT, SUSAN E · 2014 to 2018
$1.3M
NIGMS NIH HHS R01 GM111362NIH HHS R01GM111362
6 · The paper itself

Abstract

backgroundMaternal gene products supplied to the egg during oogenesis drive the earliest events of development in all metazoans. After the initial stages of embryogenesis, maternal transcripts are degraded as zygotic transcription is activated; this is known as the maternal to zygotic transition (MZT). Recently, it has been shown that the expression of maternal and zygotic transcripts have evolved in the Drosophila genus over the course of 50 million years. However, the extent of natural variation of maternal and zygotic transcripts within a species has yet to be determined. We asked how the maternal and zygotic pools of mRNA vary within and between populations of D. melanogaster. In order to maximize sampling of genetic diversity, African lines of D. melanogaster originating from Zambia as well as DGRP lines originating from North America were chosen for transcriptomic analysis.

resultsGenerally, we find that maternal transcripts are more highly conserved, and zygotic transcripts evolve at a higher rate. We find that there is more within-population variation in transcript abundance than between populations and that expression variation is highest post- MZT between African lines.

conclusionsDetermining the natural variation of gene expression surrounding the MZT in natural populations of D. melanogaster gives insight into the extent of how a tightly regulated process may vary within a species, the extent of developmental constraint at both stages and on both the maternal and zygotic genomes, and reveals expression changes allowing this species to adapt as it spread across the world.

Indexed as

Drosophila melanogasterGene Expression Regulation, DevelopmentalAnimalsDrosophilaEmbryonic DevelopmentRNA, MessengerZygoteRNA, MessengerEarly embryonic developmentEarly zygotic gene expressionExpression variationMaternal gene expression

Identifiers

PMID36076188
PMCPMC9461177
OpenAlexW4295083698

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.