Evidence map›Paper›PMID 36076124›Full record

ArticlePharmacological reports : PR2022

Vortioxetine liposomes as a novel alternative to improve drug stability under stress conditions: toxicity studies and evaluation of antidepressant-like effect.

Caroline Hermann Nodari, Natália Dalanhol De Quadros, Raquel Chiarentin, Francini Pereira Da Silva, Fernando Dal Pont Morisso, Mariele Feiffer Charão, Juliane Deise Fleck, Cristiane Bastos De Mattos, Andresa Heemann Betti, Simone Gasparin Verza

Abstract read
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In one paragraph

Article in Pharmacological reports : PR, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.7field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 10 citations in OpenAlex.

  1. An Overview of Degradation Strategies for Amitriptyline.International journal of molecular sciences · 2024
    Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Caroline Hermann NodariBioanalysis Laboratory, Institute of Health Sciences, Feevale University, 2755 Rodovia ERS 239, Novo Hamburgo, RS, CEP 93352-000, Brazil.
Natália Dalanhol De QuadrosBioanalysis Laboratory, Institute of Health Sciences, Feevale University, 2755 Rodovia ERS 239, Novo Hamburgo, RS, CEP 93352-000, Brazil.
Raquel ChiarentinBioanalysis Laboratory, Institute of Health Sciences, Feevale University, 2755 Rodovia ERS 239, Novo Hamburgo, RS, CEP 93352-000, Brazil.
Francini Pereira Da SilvaMolecular Microbiology Laboratory, Institute of Health Sciences, Feevale University, Novo Hamburgo, RS, Brazil.
Fernando Dal Pont MorissoAdvanced Materials Laboratory, Institute of Health Sciences, Feevale University, Novo Hamburgo, RS, Brazil.
Mariele Feiffer CharãoBioanalysis Laboratory, Institute of Health Sciences, Feevale University, 2755 Rodovia ERS 239, Novo Hamburgo, RS, CEP 93352-000, Brazil.
Juliane Deise FleckBioanalysis Laboratory, Institute of Health Sciences, Feevale University, 2755 Rodovia ERS 239, Novo Hamburgo, RS, CEP 93352-000, Brazil.
Cristiane Bastos De MattosBioanalysis Laboratory, Institute of Health Sciences, Feevale University, 2755 Rodovia ERS 239, Novo Hamburgo, RS, CEP 93352-000, Brazil.
Andresa Heemann BettiBioanalysis Laboratory, Institute of Health Sciences, Feevale University, 2755 Rodovia ERS 239, Novo Hamburgo, RS, CEP 93352-000, Brazil.
Simone Gasparin VerzaBioanalysis Laboratory, Institute of Health Sciences, Feevale University, 2755 Rodovia ERS 239, Novo Hamburgo, RS, CEP 93352-000, Brazil. simonev@feevale.br.ORCID http://orcid.org/0000-0001-9581-7272
Universidade Feevale · BR

Funding

National Council for Scientific and Technological Development 430938/2016-0
6 · The paper itself

Abstract

backgroundVortioxetine hydrobromide (VXT), a new therapeutic option in the treatment of major depressive disorder, is a poorly soluble drug, and instability under stress conditions has been reported. The aim of the present study was to prepare VXT liposomes (VXT-Ls) with an antidepressant-like effect, to improve drug stability and reduce toxicity of the free drug.

methodsLiposomes were prepared using the thin lipid film hydration method and properly characterized. Forced degradation studies were conducted in photolytic and oxidative conditions. The cytotoxicity was evaluated in VERO cells through MTT assay and in vivo toxicity was assessed in mice. The antidepressant-like effect in mice was confirmed using the open-field test paradigm and tail suspension test.

resultsThe optimized VXT-Ls have multilamellar vesicles with an average size of 176.74 nm ± 2.43. The liposomal formulation increased the stability of VXT. VERO cell viability was maintained at around 40% when the VXT-Ls were tested at higher concentrations and no signs of acute toxicity were observed in mice. The antidepressant-like effect was effective, for VXT-Ls, at doses ranging from 2.5 mg/kg to 10 mg/kg, measured by the tail suspension test in mice. The non-liposomal formulation was effective at a dose of 10 mg/kg. The open field test was performed and any unspecific changes in locomotor activity were revealed.

conclusionsLiposomes seem to be a promising alternative for an oral VXT formulation at lower doses (2.5 mg/kg).

Indexed as

LiposomesMajor Depressive DisorderAnimalsAntidepressive AgentsChlorocebus aethiopsDrug StabilityLipidsMiceVero CellsVortioxetineAntidepressive AgentsLipidsLiposomesVortioxetineLiposomesStabilityTail suspension testToxicityVortioxetine

Identifiers

PMID36076124
OpenAlexW4295086726

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.