Evidence map›Paper›PMID 36076097›Full record

ArticleEJNMMI physics2022

Clinical validation of a population-based input function for 20-min dynamic whole-body

André H Dias, Anne M Smith, Vijay Shah, David Pigg, Lars C Gormsen, Ole L Munk

Open access · goldAbstract read
In one paragraph

Article in EJNMMI physics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed, 1 pooled it
5.9field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 1 synthesis or guideline pooled it, 45 citations in OpenAlex.

  1. Pooled it
  2. Biological effects ofEuropean radiology · 2026
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  8. Feasibility of shortening theQuantitative imaging in medicine and surgery · 2026
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  17. Total-Body Parametric Imaging Using Relative Patlak Plot.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2025
    Article
  18. Article
  19. Article
  20. Characteristics of whole-body dynamicQuantitative imaging in medicine and surgery · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

André H DiasDepartment of Nuclear Medicine and PET Centre, Aarhus University Hospital, Palle Juul-Jensens Boulevard 165, 8200, Aarhus N, Denmark.ORCID http://orcid.org/0000-0003-3184-3468
Anne M SmithSiemens Medical Solutions USA, Inc., Knoxville, TN, USA.
Vijay ShahSiemens Medical Solutions USA, Inc., Knoxville, TN, USA.
David PiggSiemens Medical Solutions USA, Inc., Knoxville, TN, USA.
Lars C GormsenDepartment of Nuclear Medicine and PET Centre, Aarhus University Hospital, Palle Juul-Jensens Boulevard 165, 8200, Aarhus N, Denmark.ORCID http://orcid.org/0000-0002-0144-1305
Ole L MunkDepartment of Nuclear Medicine and PET Centre, Aarhus University Hospital, Palle Juul-Jensens Boulevard 165, 8200, Aarhus N, Denmark. olelajmu@rm.dk.ORCID http://orcid.org/0000-0002-7232-5088
Siemens (United States) · USAarhus University · DKAarhus University Hospital · DK

Funding

Novo Nordisk Fonden NNF19OC0055100
6 · The paper itself

Abstract

purposeContemporary PET/CT scanners can use 70-min dynamic whole-body (D-WB) PET to generate more quantitative information about FDG uptake than just the SUV by generating parametric images of FDG metabolic rate (MR

methodsA PBIF was calculated based on AIFs from 20 patients that were D-WB PET scanned for 120 min with simultaneous arterial blood sampling. MR

resultsWe found excellent agreement between the AIF and IDIF at all times. For the clinical validation, the use of sPBIF led to an acceptable AUC bias of 1-5% in most subgroups except for patients with diabetes or patients with low eGFR, where the biases were marginally higher at 7%. Multiparametric MR

conclusionsA short 20-min D-WB PET examination using PBIF can be used for multiparametric imaging without compromising the image quality or precision of MR

Indexed as

AIFDynamic whole-body PETFDGInput functionParametric imagingPatlakPBIF

Identifiers

PMID36076097
PMCPMC9458803
OpenAlexW4294970400

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.