Evidence map›Paper›PMID 36076088›Full record

ArticleNeuroradiology2022

Intracerebral hemorrhage markers on non-contrast computed tomography as predictors of the dynamic spot sign on CT perfusion and associations with hematoma expansion and outcome.

Michael Quangminh Truong, Andrew Viggo Metcalfe, Christopher Dillon Ovenden, Timothy John Kleinig, Christen David Barras

Erratum issuedAbstract read
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In one paragraph

Article in Neuroradiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
0.6field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it, 6 citations in OpenAlex.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Michael Quangminh TruongDepartment of Radiology, Royal Adelaide Hospital, Adelaide, South Australia, Australia. Michael.truong@sa.gov.au.ORCID http://orcid.org/0000-0003-3448-2792
Andrew Viggo MetcalfeSchool of Mathematical Sciences, The University of Adelaide, Adelaide, South Australia, Australia.ORCID http://orcid.org/0000-0002-7680-3577
Christopher Dillon OvendenFaculty of Health and Medical Sciences, Surgical Specialties, The University of Adelaide, Adelaide, South Australia, Australia.
Timothy John KleinigDepartment of Neurology, Royal Adelaide Hospital, Adelaide, South Australia, Australia.ORCID http://orcid.org/0000-0003-4430-3276
Christen David BarrasDepartment of Radiology, Royal Adelaide Hospital, Adelaide, South Australia, Australia.ORCID http://orcid.org/0000-0003-1899-1909
Royal Adelaide Hospital · AUThe University of Adelaide · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo assess the association between non-contrast computed tomography (NCCT) hematoma markers and the dynamic spot sign on computed tomography perfusion (CTP), and their associations with hematoma expansion, clinical outcome, and in-hospital mortality.

methodsPatients who presented with intracerebral hemorrhage (ICH) to a stroke center over an 18-month period and underwent baseline NCCT and CTP, and a follow-up NCCT within 24 h after the baseline scan were included. The initial and follow-up hematoma volumes were calculated. Two raters independently assessed the baseline NCCT for hematoma markers and concurrently assessed the CTP for the dynamic spot sign. Univariate and multivariate logistic regression analyses were performed to assess the association between the hematoma markers and the dynamic spot sign, adjusting for known ICH expansion predictors.

resultsEighty-five patients were included in our study and 55 patients were suitable for expansion analysis. Heterogeneous density was the only NCCT hematoma marker to be associated with the dynamic spot sign after multivariate analysis (odds ratio, 58.61; 95% confidence interval, 9.13-376.05; P < 0.001). The dynamic spot sign was present in 22 patients (26%) and significantly predicted hematoma expansion (odds ratio, 36.6; 95% confidence interval, 2.51-534.2; P = 0.008). All patients with a spot sign had a swirl sign. A co-located hypodensity and spot sign was significantly associated with in-hospital mortality (odds ratio, 6.17; 95% confidence interval, 1.09-34.78; P = 0.039).

conclusionHeterogeneous density and swirl sign are associated with the dynamic spot sign. The dynamic spot sign is a stronger predictor than NCCT hematoma markers of significant hematoma expansion. A co-located spot sign and hypodensity predicts in-hospital mortality.

Indexed as

Cerebral HemorrhageHematomaBiomarkersCerebral AngiographyComputed Tomography AngiographyHumansPerfusionTomography, X-Ray ComputedBiomarkersCT perfusionHematoma expansionHematoma markersIntracerebral hemorrhageSpot sign

Identifiers

PMID36076088
OpenAlexW4295077829

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.