Evidence map›Paper›PMID 36076020›Full record

ArticleNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology2023

Serum amyloid P component (SAP) modulates antidepressant effects through promoting membrane insertion of the serotonin transporter.

Ping Su, Shuxin Yan, Jian Yang, Junchao Tong, James Samsom, Fan You, Yun Li, Qiuyue Chen, Anlong Jiang, Dongxu Zhai and 10 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.4field-weighted citation impact, top 52% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. The Complex Role of Serotonin-Dopamine-Glutamate Receptors in Major Depression.Advances in experimental medicine and biology · 2026
    Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors at 4 institutions in 2 countries.

Ping Su *Advanced Innovation Center for Human Brain Protection, Capital Medical University, Beijing, China, Beijing, China.
Shuxin Yan *Advanced Innovation Center for Human Brain Protection, Capital Medical University, Beijing, China, Beijing, China.
Jian Yang *Beijing AnDing Hospital, Capital Medical University, Beijing, China, Beijing, China.
Junchao TongCampbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, ON, Canada.ORCID 0000-0001-9299-0045
James SamsomCampbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, ON, Canada.
Fan YouAdvanced Innovation Center for Human Brain Protection, Capital Medical University, Beijing, China, Beijing, China.
Yun LiAdvanced Innovation Center for Human Brain Protection, Capital Medical University, Beijing, China, Beijing, China.
Qiuyue ChenAdvanced Innovation Center for Human Brain Protection, Capital Medical University, Beijing, China, Beijing, China.
Anlong JiangCampbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, ON, Canada.
Dongxu ZhaiCampbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, ON, Canada.
Jiahao ChenDepartments of Neurobiology and Pathology, Beijing Key Laboratory of Neural Regeneration and Repair, Capital Medical University, Beijing, 100069, China.
Zuoli SunBeijing AnDing Hospital, Capital Medical University, Beijing, China, Beijing, China.
Jingjing ZhouBeijing AnDing Hospital, Capital Medical University, Beijing, China, Beijing, China.
Min LiuBeijing AnDing Hospital, Capital Medical University, Beijing, China, Beijing, China.
Frank J S LeeFaculty of Health Sciences, Simon Fraser University, Burnaby, BC, Canada.
Zhi-Qing David XuDepartments of Neurobiology and Pathology, Beijing Key Laboratory of Neural Regeneration and Repair, Capital Medical University, Beijing, 100069, China.
Xin WangDepartment of Hematology, Shandong Provincial Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, 250021, China.
Neil VasdevCampbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, ON, Canada.
Albert H C WongCampbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, ON, Canada.
Fang LiuAdvanced Innovation Center for Human Brain Protection, Capital Medical University, Beijing, China, Beijing, China. fang.liu@camh.ca.
Capital Medical University · CNCentre for Addiction and Mental Health · CAShandong University · CNSimon Fraser University · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Serum amyloid P component (SAP) is a universal constituent of human amyloid deposits including those in Alzheimer's disease. SAP has been observed to be elevated in patients with depression, and higher SAP levels are associated with better response to the antidepressant escitalopram. The mechanisms underlying these clinical observations remain unclear. We examined the effect of SAP on serotonin transporter (SERT) expression and localization using Western blot, confocal microscopy, and positron emission tomography with the radioligand [

Indexed as

Serotonin Plasma Membrane Transport ProteinsSerum Amyloid P-ComponentAnimalsAntidepressive AgentsEscitalopramHumansMiceSelective Serotonin Reuptake InhibitorsAntidepressive AgentsEscitalopramSelective Serotonin Reuptake InhibitorsSerotonin Plasma Membrane Transport ProteinsSerum Amyloid P-Component

Identifiers

PMID36076020
PMCPMC9852251
OpenAlexW4295077933

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.