Evidence map›Paper›PMID 36076000›Full record

ArticleNeurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology2022

Myasthenia gravis treated in the neurology intensive care unit: a 14-year single-centre experience.

Mirjana Zdraljevic, Stojan Peric, Marta Jeremic, Dragana Lavrnic, Ivana Basta, Ljiljana Hajdukovic, Dejana R Jovanovic, Ivana Berisavac

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Article in Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
0.5field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it, 4 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Mirjana Zdraljevic *Neurology Clinic, University Clinical Center of Serbia, Dr Subotic Street 6, 11 000, Belgrade, Serbia.
Stojan Peric *Neurology Clinic, University Clinical Center of Serbia, Dr Subotic Street 6, 11 000, Belgrade, Serbia.
Marta JeremicNeurology Clinic, University Clinical Center of Serbia, Dr Subotic Street 6, 11 000, Belgrade, Serbia.
Dragana LavrnicNeurology Clinic, University Clinical Center of Serbia, Dr Subotic Street 6, 11 000, Belgrade, Serbia.
Ivana BastaNeurology Clinic, University Clinical Center of Serbia, Dr Subotic Street 6, 11 000, Belgrade, Serbia.
Ljiljana HajdukovicInstitute for Application of Nuclear Energy, University of Belgrade, Banatska 31b, 11080, Zemun, Belgrade, Serbia.
Dejana R JovanovicNeurology Clinic, University Clinical Center of Serbia, Dr Subotic Street 6, 11 000, Belgrade, Serbia.
Ivana BerisavacNeurology Clinic, University Clinical Center of Serbia, Dr Subotic Street 6, 11 000, Belgrade, Serbia. ivanaberisavac@gmail.com.ORCID http://orcid.org/0000-0002-3637-9935
University of Belgrade · RSCentar za Promociju Nauke · RS

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionSevere myasthenia gravis (MG) exacerbation with respiratory failure and/or dysphagia usually requires monitoring and treatment in the neurology intensive care unit (NICU). The aim of our study was to identify all patients with severe MG exacerbation treated in the NICU in order to assessed potential factors affecting patients' need for mechanical ventilation, occurrence of complications and the final outcome.

methodsWe retrospectively included all patients with severe exacerbation of MG who required management in the NICU during a 14-year period. Baseline sociodemographic and clinical features, data on medication, comorbidities and outcome were obtained by reviewing medical records and institutional databases.

resultsOur study comprised 130 severe MG exacerbations detected in 118 patients. Median age of patients was 61.5 years, and women accounted for 58.5% of the patients. Half of the patients required mechanical ventilation during hospitalization. Lethal outcome was observed in 12.3% of severe MG exacerbations. Only elder age was an independent negative predictor of survival (OR 0.89, 95% CI 0.82-0.97, p < 0.01). Complications during hospitalization were detected in 50% of patients. A higher number of comorbidities (OR 1.09, 95% CI 1.60-2.35, p = 0.01) and mechanical ventilation (OR 28.48, 95% CI 8.56-94.81, p < 0.01) were independent predictors of complications during hospitalization.

conclusionPatients with a severe MG exacerbation who do not require mechanical ventilation have a good outcome after treatment in the NICU. Elder age is an independent predictor of lethal outcome in patients with severe MG exacerbation. Mechanical ventilation and a higher number of comorbidities lead to more frequent complications.

Indexed as

Myasthenia GravisNeurologyAgedFemaleHumansIntensive Care UnitsMiddle AgedRespiration, ArtificialRetrospective StudiesExacerbationIntensive careMyasthenia gravisOutcomePredictors

Identifiers

PMID36076000
OpenAlexW4295086853

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.