Evidence map›Paper›PMID 36075947›Full record

ReviewExperimental & molecular medicine2022

Tracing the lactate shuttle to the mitochondrial reticulum.

George A Brooks, Casey C Curl, Robert G Leija, Adam D Osmond, Justin J Duong, Jose A Arevalo

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Experimental & molecular medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 66 papers.

0numbers the graph read from it
0cells of the map it votes in
66citing papers in PubMed
5.7field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

66 citing papers in PubMed, 78 citations in OpenAlex.

  1. Review
  2. LDH isozymes as targets for cancer therapy.Journal of enzyme inhibition and medicinal chemistry · 2026
    Review
  3. Lactate Signal: Modulator of Cellular Energy Production and Anabolism.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Review
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  19. L-lactic acid enhances type I interferon immune response and inhibits virus infection by promoting IRF9 L-lactylation.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  20. Review

6 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

George A BrooksExercise Physiology Laboratory, Department of Integrative Biology, University of California, Berkeley, CA, 94720-3140, USA. gbrooks@berkeley.edu.ORCID 0000-0002-1389-1629
Casey C CurlExercise Physiology Laboratory, Department of Integrative Biology, University of California, Berkeley, CA, 94720-3140, USA.
Robert G LeijaExercise Physiology Laboratory, Department of Integrative Biology, University of California, Berkeley, CA, 94720-3140, USA.
Adam D OsmondExercise Physiology Laboratory, Department of Integrative Biology, University of California, Berkeley, CA, 94720-3140, USA.
Justin J DuongExercise Physiology Laboratory, Department of Integrative Biology, University of California, Berkeley, CA, 94720-3140, USA.
Jose A ArevaloExercise Physiology Laboratory, Department of Integrative Biology, University of California, Berkeley, CA, 94720-3140, USA.
University of California, Berkeley · US

Funding

Aging Mitochondrial Fragmentation and Metabolic InflexibilityR01AG059715 · NIA · UNIVERSITY OF CALIFORNIA BERKELEY · PI BROOKS, GEORGE AUSTIN · 2018 to 2022
$3.0M
NIA NIH HHS R01 AG059715
6 · The paper itself

Abstract

Isotope tracer infusion studies employing lactate, glucose, glycerol, and fatty acid isotope tracers were central to the deduction and demonstration of the Lactate Shuttle at the whole-body level. In concert with the ability to perform tissue metabolite concentration measurements, as well as determinations of unidirectional and net metabolite exchanges by means of arterial-venous difference (a-v) and blood flow measurements across tissue beds including skeletal muscle, the heart and the brain, lactate shuttling within organs and tissues was made evident. From an extensive body of work on men and women, resting or exercising, before or after endurance training, at sea level or high altitude, we now know that Organ-Organ, Cell-Cell, and Intracellular Lactate Shuttles operate continuously. By means of lactate shuttling, fuel-energy substrates can be exchanged between producer (driver) cells, such as those in skeletal muscle, and consumer (recipient) cells, such as those in the brain, heart, muscle, liver and kidneys. Within tissues, lactate can be exchanged between white and red fibers within a muscle bed and between astrocytes and neurons in the brain. Within cells, lactate can be exchanged between the cytosol and mitochondria and between the cytosol and peroxisomes. Lactate shuttling between driver and recipient cells depends on concentration gradients created by the mitochondrial respiratory apparatus in recipient cells for oxidative disposal of lactate.

Indexed as

GlycerolLactic AcidEndoplasmic Reticulum StressFatty AcidsFemaleGlucoseHumansMaleMitochondriaMuscle, SkeletalFatty AcidsGlucoseGlycerolLactic Acid

Identifiers

PMID36075947
PMCPMC9534995
OpenAlexW4295083465

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.