Evidence map›Paper›PMID 36075936›Full record

ArticleScientific reports2022

Tau isoform-specific enhancement of L-type calcium current and augmentation of afterhyperpolarization in rat hippocampal neurons.

Georgiana F Stan, Timothy W Church, Ellie Randall, Jenna R M Harvey, Jon T Brown, Kevin A Wilkinson, Jonathan G Hanley, Neil V Marrion

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.7field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
  2. Article
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  5. Review
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Georgiana F StanSchool of Biochemistry, University of Bristol, Bristol, BS8 1TD, UK.
Timothy W ChurchSchool of Physiology, Pharmacology and Neuroscience, University of Bristol, Bristol, BS8 1TD, UK.
Ellie RandallSchool of Physiology, Pharmacology and Neuroscience, University of Bristol, Bristol, BS8 1TD, UK.
Jenna R M HarveySchool of Physiology, Pharmacology and Neuroscience, University of Bristol, Bristol, BS8 1TD, UK.
Jon T BrownUniversity of Exeter Medical School, Hatherly Building, Exeter, EX4 4QJ, UK.
Kevin A WilkinsonSchool of Biochemistry, University of Bristol, Bristol, BS8 1TD, UK.
Jonathan G HanleySchool of Biochemistry, University of Bristol, Bristol, BS8 1TD, UK.
Neil V MarrionSchool of Physiology, Pharmacology and Neuroscience, University of Bristol, Bristol, BS8 1TD, UK. N.V.Marrion@bristol.ac.uk.
University of Bristol · GBUniversity of Exeter · GB

Funding

British Heart Foundation PG/16/37/31974
6 · The paper itself

Abstract

Accumulation of tau is observed in dementia, with human tau displaying 6 isoforms grouped by whether they display either 3 or 4 C-terminal repeat domains (3R or 4R) and exhibit no (0N), one (1N) or two (2N) N terminal repeats. Overexpression of 4R0N-tau in rat hippocampal slices enhanced the L-type calcium (Ca

Indexed as

CalciumTauopathiesAnimalsCalcium Channels, L-TypeCalcium, DietaryHippocampusHumansNeuronsProtein IsoformsRatstau ProteinsCalciumCalcium Channels, L-TypeCalcium, DietaryProtein Isoformstau Proteins

Identifiers

PMID36075936
PMCPMC9458744
OpenAlexW4294956089

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.