Evidence map›Paper›PMID 36075933›Full record

ArticleNature communications2022

Structural basis for gating mechanism of the human sodium-potassium pump.

Phong T Nguyen, Christine Deisl, Michael Fine, Trevor S Tippetts, Emiko Uchikawa, Xiao-Chen Bai, Beth Levine

Open access · goldAbstract read
In one paragraph

Article in Nature communications, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed
4.0field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 49 citations in OpenAlex.

  1. Clinical and Genetic Spectrum ofNeurology. Genetics · 2026
    Article
  2. Article
  3. Active conformations of neuronal NaNature communications · 2026
    Article
  4. Article
  5. Article
  6. Article
  7. Signaling architecture of the glucagon-like peptide-1 receptor.The Journal of clinical investigation · 2026
    Review
  8. Review
  9. Article
  10. Article
  11. Article
  12. Review
  13. Multistate Kinetic Model of the Sodium-Potassium ATPase.The journal of physical chemistry. B · 2025
    Article
  14. Review
  15. Review
  16. Review
  17. Review
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Phong T NguyenHoward Hughes Medical Institute and Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX, USA. phong.nguyen@utsouthwestern.edu.
Christine DeislDepartment of Physiology, University of Texas Southwestern Medical Center, Dallas, TX, USA.ORCID 0000-0002-1650-855X
Michael FineDepartment of Physiology, University of Texas Southwestern Medical Center, Dallas, TX, USA.ORCID 0000-0002-8436-3073
Trevor S TippettsChildren's Research Institute, University of Texas Southwestern Medical Center, Dallas, TX, USA.ORCID 0000-0002-1419-7057
Emiko UchikawaDepartment of Biophysics, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Xiao-Chen BaiDepartment of Biophysics, University of Texas Southwestern Medical Center, Dallas, TX, USA. xiaochen.bai@utsouthwestern.edu.ORCID 0000-0002-4234-5686
Beth LevineHoward Hughes Medical Institute and Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX, USA.
The University of Texas Southwestern Medical Center · USHoward Hughes Medical Institute · USSouthwestern Medical Center · US

Funding

Structural and Functional Analyses of the Full-length Insulin Receptor (IR) and Type 1 Insulin-like Growth Factor Receptor (IGF1R) in the Liganded Active StateR01GM136976 · NIGMS · UT SOUTHWESTERN MEDICAL CENTER · PI BAI, XIAOCHEN · 2020 to 2024
$1.8M
Howard Hughes Medical InstituteNIGMS NIH HHS R01 GM136976
6 · The paper itself

Abstract

P2-type ATPase sodium-potassium pumps (Na

Indexed as

SodiumSodium-Potassium-Exchanging ATPaseAdenosine DiphosphateAdenosine TriphosphateAnimalsCryoelectron MicroscopyHumansIonsPotassiumAdenosine DiphosphateAdenosine TriphosphateIonsPotassiumSodiumSodium-Potassium-Exchanging ATPase

Identifiers

PMID36075933
PMCPMC9458724
OpenAlexW4294958700

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.