Evidence map›Paper›PMID 36075909›Full record

ArticleSignal transduction and targeted therapy2022

Pro-senescence neddylation inhibitor combined with a senescence activated β-galactosidase prodrug to selectively target cancer cells.

Shuaishuai Ni, Qian Liu, Xin Chen, Lele Ding, Lili Cai, Fei Mao, Donglei Shi, Robert M Hoffman, Jian Li, Lijun Jia

Abstract readLetter
PubMed Full text at PMC Publisher
In one paragraph

Article in Signal transduction and targeted therapy, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Review
  5. Review
  6. Article
  7. Review
  8. Article
  9. Senolytic Prodrugs: A Promising Approach to Enhancing Senescence-Targeting Intervention.Chembiochem : a European journal of chemical biology · 2024
    Review
  10. Article
  11. Article
  12. Review
  13. Senolysis Enabled by Senescent Cell-Sensitive Bioorthogonal Tetrazine Ligation.Angewandte Chemie (International ed. in English) · 2024
    Article
  14. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Shuaishuai Ni *Cancer Institute, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, 200032, Shanghai, China.
Qian Liu *Cancer Institute, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, 200032, Shanghai, China.
Xin Chen *State Key Laboratory of Bioreactor Engineering, Shanghai Frontiers Science Center of Optogenetic Techniques for Cell Metabolism, Frontiers Science Center for Materiobiology and Dynamic Chemistry, Shanghai Key Laboratory of New Drug Design, School of Pharmacy, East China University of Science and Technology, 200037, Shanghai, China.
Lele Ding *Cancer Institute, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, 200032, Shanghai, China.
Lili CaiCancer Institute, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, 200032, Shanghai, China.
Fei MaoState Key Laboratory of Bioreactor Engineering, Shanghai Frontiers Science Center of Optogenetic Techniques for Cell Metabolism, Frontiers Science Center for Materiobiology and Dynamic Chemistry, Shanghai Key Laboratory of New Drug Design, School of Pharmacy, East China University of Science and Technology, 200037, Shanghai, China.ORCID 0000-0001-5871-6878
Donglei ShiState Key Laboratory of Bioreactor Engineering, Shanghai Frontiers Science Center of Optogenetic Techniques for Cell Metabolism, Frontiers Science Center for Materiobiology and Dynamic Chemistry, Shanghai Key Laboratory of New Drug Design, School of Pharmacy, East China University of Science and Technology, 200037, Shanghai, China.
Robert M HoffmanDepartment of Surgery, University of California, San Diego, CA, USA.
Jian LiState Key Laboratory of Bioreactor Engineering, Shanghai Frontiers Science Center of Optogenetic Techniques for Cell Metabolism, Frontiers Science Center for Materiobiology and Dynamic Chemistry, Shanghai Key Laboratory of New Drug Design, School of Pharmacy, East China University of Science and Technology, 200037, Shanghai, China. jianli@ecust.edu.cn.ORCID 0000-0002-7521-8798
Lijun JiaCancer Institute, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, 200032, Shanghai, China. ljjia@shutcm.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

NeoplasmsProdrugsbeta-GalactosidaseNEDD8 Proteinbeta-GalactosidaseNEDD8 ProteinProdrugs

Identifiers

PMID36075909
PMCPMC9458665

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.