Evidence map›Paper›PMID 36075771›Full record

ArticleJournal of pediatric surgery2023

Management of pediatric appendicitis during the COVID-19 pandemic: A nationwide multicenter cohort study.

Brittany Hegde, Elisa Garcia, Andrew Hu, Mehul Raval, Sanyu Takirambudde, Derek Wakeman, Ruth Lewit, Ankush Gosain, Raphael H Parrado, Robert A Cina and 28 more

Abstract readMulticenter Study
In one paragraph

Article in Journal of pediatric surgery, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

38 authors.

Brittany HegdeDepartment of Pediatric Surgery, McGovern Medical School at the University of Texas Health Science Center at Houston, 6431 Fannin Street, MSB 5.256, Houston, TX 77030, United States of America; Center for Surgical Trials and Evidence-based Practice (C-STEP), McGovern Medical School at the University of Texas Health Science Center at Houston, 6431 Fannin Street, MSB 5.256, Houston, TX 77030, United States of America; Children's Memorial Hermann Hospital, 6411 Fannin Street, Houston, TX 77030, United States of America.
Elisa GarciaDepartment of Pediatric Surgery, McGovern Medical School at the University of Texas Health Science Center at Houston, 6431 Fannin Street, MSB 5.256, Houston, TX 77030, United States of America; Children's Memorial Hermann Hospital, 6411 Fannin Street, Houston, TX 77030, United States of America.
Andrew HuDivision of Pediatric Surgery, Department of Surgery, Northwestern University Feinberg School of Medicine, Ann & Robert H. Lurie Children's Hospital of Chicago, 225 E. Chicago Ave, Chicago, IL 60611, United States of America.
Mehul RavalDivision of Pediatric Surgery, Department of Surgery, Northwestern University Feinberg School of Medicine, Ann & Robert H. Lurie Children's Hospital of Chicago, 225 E. Chicago Ave, Chicago, IL 60611, United States of America.
Sanyu TakirambuddeUniversity of Rochester School of Medicine and Dentistry, 601 Elmwood Ave, Rochester, NY 14642, United States of America.
Derek WakemanUniversity of Rochester School of Medicine and Dentistry, 601 Elmwood Ave, Rochester, NY 14642, United States of America.
Ruth LewitUniversity of Tennessee Health Science Center, LeBonheur Children's Hospital, 49 North Dunlap, Memphis, TN 38103, United States of America.
Ankush GosainUniversity of Tennessee Health Science Center, LeBonheur Children's Hospital, 49 North Dunlap, Memphis, TN 38103, United States of America.
Raphael H ParradoMedical University of South Carolina, Shawn Jenkins Children's Hospital, 10 McClennan Banks Drive, Charleston, SC 29425, United States of America.
Robert A CinaMedical University of South Carolina, Shawn Jenkins Children's Hospital, 10 McClennan Banks Drive, Charleston, SC 29425, United States of America.
Krista StephensonArkansas Children's Hospital, 1 Children's Way, Slot 837, Little Rock, AR 72202, United States of America.
Melvin S DassingerArkansas Children's Hospital, 1 Children's Way, Slot 837, Little Rock, AR 72202, United States of America.
Daniel ZhangUniversity of Florida Health Shands Children's Hospital, 1515 SW Archer Rd, Gainesville, FL 32608, United States of America.
Moiz M MustafaUniversity of Florida Health Shands Children's Hospital, 1515 SW Archer Rd, Gainesville, FL 32608, United States of America.
Donna KooCohen Children's Medical Center, Zucker School of Medicine at Hofstra/Northwell, Division of Pediatric Surgery, 1111 Marcus Avenue, Ste M15, New Hyde Park, NY 11042, United States of America.
Aaron M LipskarCohen Children's Medical Center, Zucker School of Medicine at Hofstra/Northwell, Division of Pediatric Surgery, 1111 Marcus Avenue, Ste M15, New Hyde Park, NY 11042, United States of America.
Katherine ScheidlerDivision of Pediatric Surgery, Medical College of Wisconsin, 999N 92nd St, Suite 320, Milwaukee, WI 53226, United States of America.
Kyle J Van ArendonkDivision of Pediatric Surgery, Medical College of Wisconsin, 999N 92nd St, Suite 320, Milwaukee, WI 53226, United States of America.
Patrick BergUniversity of California Davis, School of Medicine, Department of Surgery, Division of Trauma, Acute Care Surgery, and Surgical Critical Care, 2335 Stockton Blvd. 5th floor, Sacramento, CA 95817, United States of America.
Raquel GonzalezJohns Hopkins All Children's Hospital, 601 5th Street South, Suite 611, St. Petersburg, FL 33701, United States of America.
Daniel ScheeseChildrens Hospital of Richmond, VCU Health System, 1200 E Marshall St, Richmond, VA 23298, United States of America.
Jeffrey HaynesChildrens Hospital of Richmond, VCU Health System, 1200 E Marshall St, Richmond, VA 23298, United States of America.
Alexander MinaVanderbilt University Medical Center, 2200 Children's Way, DOT 7, Nashville, TN 37212, United States of America.
Irving J ZamoraVanderbilt University Medical Center, 2200 Children's Way, DOT 7, Nashville, TN 37212, United States of America.
Monica E LopezVanderbilt University Medical Center, 2200 Children's Way, DOT 7, Nashville, TN 37212, United States of America.
Steven C MehlTexas Children's Hospital, Baylor College of Medicine, 6701 Fannin Street, Suite 1210, Houston, TX 77030, United States of America.
Elizabeth GilliamOregon Health and Science University, Division of Pediatric Surgery, 3181 SW Sam Jackson Rd, Portland, OR 97239, United States of America.
Katrina LofbergOregon Health and Science University, Division of Pediatric Surgery, 3181 SW Sam Jackson Rd, Portland, OR 97239, United States of America.
Brianna SpencerPenn State Health Children's Hospital, 600 University Drive, Hershey, PA 17033, United States of America.
Afif N KulaylatPenn State Health Children's Hospital, 600 University Drive, Hershey, PA 17033, United States of America.
Brian C GulackRush University Medical Center, Department of Surgery, 1653W. Congress Pkwy, Chicago, IL 60612, United States of America.
Matthew JohnsonRush University Medical Center, Department of Surgery, 1653W. Congress Pkwy, Chicago, IL 60612, United States of America.
Matthew LaskovyBeaumont Health, Department of Surgery, 3811 West 13 Mile Rd, Suite e181, Royal Oak, MI 48073, United States of America.
Pavan BrahmamdamBeaumont Health, Department of Surgery, 3811 West 13 Mile Rd, Suite e181, Royal Oak, MI 48073, United States of America.
Aoi ShimomuraLoyola University Chicago, Stritch School of Medicine, 2160 S 1st Avenue, Maywood, IL 60153, United States of America.
Therese BlanchLoyola University Chicago, Stritch School of Medicine, 2160 S 1st Avenue, Maywood, IL 60153, United States of America.
KuoJen TsaoDepartment of Pediatric Surgery, McGovern Medical School at the University of Texas Health Science Center at Houston, 6431 Fannin Street, MSB 5.256, Houston, TX 77030, United States of America; Center for Surgical Trials and Evidence-based Practice (C-STEP), McGovern Medical School at the University of Texas Health Science Center at Houston, 6431 Fannin Street, MSB 5.256, Houston, TX 77030, United States of America; Children's Memorial Hermann Hospital, 6411 Fannin Street, Houston, TX 77030, United States of America.
Bethany J SlaterComer Children's Hospital, University of Chicago, 5721 S Maryland Avenue, Chicago, IL 60637, United States of America. Electronic address: bslater@surgery.bsd.uchicago.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe COVID-19 pandemic has impacted timely access to care for children, including patients with appendicitis. This study aimed to evaluate the effect of the COVID-19 pandemic on management of appendicitis and patient outcomes.

methodsA multicenter retrospective study was performed including 19 children's hospitals from April 2019-October 2020 of children (age≤18 years) diagnosed with appendicitis. Groups were defined by each hospital's city/state stay-at-home orders (SAHO), designating patients as Pre-COVID (Pre-SAHO) or COVID (Post-SAHO). Demographic, treatment, and outcome data were obtained, and univariate and multivariable analysis was performed.

resultsOf 6,014 patients, 2,413 (40.1%) presented during the COVID-19 pandemic. More patients were managed non-operatively during the COVID-19 pandemic compared to before the pandemic (147 (6.1%) vs 144 (4.0%), p < 0.001). Despite this change, there was no difference in the proportion of complicated appendicitis between groups (1,247 (34.6%) vs 849 (35.2%), p = 0.12). COVID era non-operative patients received fewer additional procedures, including interventional radiology (IR) drain placements, compared to pre-COVID non-operative patients (29 (19.7%) vs 69 (47.9%), p < 0.001). On adjusted analysis, factors associated with increased odds of receiving non-operative management included: increasing duration of symptoms (OR=1.01, 95% CI: 1.01-1.012), African American race (OR=2.4, 95% CI: 1.3-4.6), and testing positive for COVID-19 (OR=10.8, 95% CI: 5.4-21.6).

conclusionNon-operative management of appendicitis increased during the COVID-19 pandemic. Additionally, fewer COVID era cases required IR procedures. These changes in the management of pediatric appendicitis during the COVID pandemic demonstrates the potential for future utilization of non-operative management.

Indexed as

AppendicitisCOVID-19AdolescentAppendectomyBlack or African AmericanChildHumansPandemicsRetrospective StudiesCOVID-19Non-operative managementPatient outcomesPediatric appendicitisSARS-CoV-2Stay at home order

Identifiers

PMID36075771
PMCPMC9374489

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.