Evidence map›Paper›PMID 36075621›Full record

ArticleJACC. Cardiovascular imaging2022

Coronary Atherosclerosis in an Asymptomatic U.S. Population: Miami Heart Study at Baptist Health South Florida.

Khurram Nasir, Miguel Cainzos-Achirica, Javier Valero-Elizondo, Shozab S Ali, Ruby Havistin, Suvasini Lakshman, Michael J Blaha, Ron Blankstein, Michael D Shapiro, Lara Arias and 6 more

Abstract read
PubMed Publisher
In one paragraph

Article in JACC. Cardiovascular imaging, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
48citing papers in PubMed, 1 pooled it
9.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

48 citing papers in PubMed, 1 synthesis or guideline pooled it, 76 citations in OpenAlex.

  1. Pooled it
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  7. Opportunistic Screening on Chest CT, From theAJR. American journal of roentgenology · 2026
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

16 authors at 8 institutions in 1 country.

Khurram NasirDivision of Cardiovascular Prevention and Wellness, Department of Cardiology, Houston Methodist DeBakey Heart & Vascular Center, Houston, Texas, USA; Center for Outcomes Research, Houston Methodist, Houston, Texas, USA; Ciccarone Center for the Prevention of Cardiovascular Disease, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA. Electronic address: knasir@houstonmethodist.org.
Miguel Cainzos-AchiricaDivision of Cardiovascular Prevention and Wellness, Department of Cardiology, Houston Methodist DeBakey Heart & Vascular Center, Houston, Texas, USA; Center for Outcomes Research, Houston Methodist, Houston, Texas, USA; Ciccarone Center for the Prevention of Cardiovascular Disease, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Javier Valero-ElizondoDivision of Cardiovascular Prevention and Wellness, Department of Cardiology, Houston Methodist DeBakey Heart & Vascular Center, Houston, Texas, USA; Center for Outcomes Research, Houston Methodist, Houston, Texas, USA.
Shozab S AliMiami Cardiac and Vascular Institute, Baptist Health South Florida, Miami, Florida, USA; Herbert Wertheim College of Medicine, Florida International University, Miami, Florida, USA.
Ruby HavistinHarbor-UCLA Medical Center, Torrance, California, USA.
Suvasini LakshmanHarbor-UCLA Medical Center, Torrance, California, USA.
Michael J BlahaCiccarone Center for the Prevention of Cardiovascular Disease, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Ron BlanksteinBrigham and Women's Hospital Heart and Vascular Center, and Harvard Medical School, Boston, Massachusetts, USA.
Michael D ShapiroCenter for Prevention of Cardiovascular Disease, Section on Cardiovascular Medicine, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA.
Lara AriasMiami Cardiac and Vascular Institute, Baptist Health South Florida, Miami, Florida, USA.
Anshul SaxenaMiami Cardiac and Vascular Institute, Baptist Health South Florida, Miami, Florida, USA.
Theodore FeldmanMiami Cardiac and Vascular Institute, Baptist Health South Florida, Miami, Florida, USA; Herbert Wertheim College of Medicine, Florida International University, Miami, Florida, USA.
Matthew J BudoffHarbor-UCLA Medical Center, Torrance, California, USA; David Geffen School of Medicine, University of California, Los Angeles, California, USA.
Jack A ZifferMiami Cardiac and Vascular Institute, Baptist Health South Florida, Miami, Florida, USA.
Jonathan FialkowMiami Cardiac and Vascular Institute, Baptist Health South Florida, Miami, Florida, USA.
Ricardo C CuryMiami Cardiac and Vascular Institute, Baptist Health South Florida, Miami, Florida, USA; Herbert Wertheim College of Medicine, Florida International University, Miami, Florida, USA. Electronic address: rcury@baptisthealth.net.
Baptist Health South Florida · USBaptist Hospital of Miami · USHouston Methodist · USUCLA Medical Center · USBrigham and Women's Hospital · USJohns Hopkins University · USUniversity of California, Los Angeles · USWake Forest University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe burden of total coronary plaque, plaque subtypes, and high-risk plaque features was unknown in asymptomatic individuals from the general U.S. primary prevention population.

objectivesIn a large, asymptomatic U.S. cohort evaluated using coronary computed tomography angiography (CCTA), we aimed to assess the burden of total coronary plaque, plaque subtypes, and high-risk plaque features; the interplay between CCTA findings and coronary artery calcium (CAC) scores; and identify independent predictors of coronary plaque.

methodsCross-sectional analysis in the MiHeart (Miami Heart Study), a cohort of 2,359 asymptomatic individuals from the Greater Miami Area (mean age 53 years, 50% women, 47% Hispanic/Latino, 43% non-Hispanic White). We estimated the burden of CAC (=0, >0 to <100, ≥100), CCTA-based plaque features (any plaque, stenosis ≥50%, ≥70%, high-risk features), and their interplay.

resultsOverall, 58% participants had CAC = 0, 28% CAC >0 to <100, and 13% CAC ≥100. A total of 49% participants had plaque on the CCTA, including 16% among those with CAC = 0. Overall, 6% participants had coronary stenosis ≥50% (12% among those with coronary plaque), 1.8% had stenosis ≥70% (3.7% among those with plaque), and 7% had at least 1 coronary plaque with ≥1 high-risk feature (13.8% among those with plaque). Only 0.8% participants with CAC = 0 had stenosis ≥50%, 0.1% stenosis ≥70%, and 2.3% plaque with high-risk features. In logistic regression models, independent predictors of coronary plaque and high-risk plaque were older age, male sex, tobacco use, diabetes, overweight, and obesity. Male sex, overweight, and obesity were independent predictors of plaque if CAC = 0.

conclusionsThe Miami Heart Study confirms substantial prevalence of coronary plaque in asymptomatic individuals. Overall, 49% of participants had coronary plaque, 6% had stenosis ≥50%, and 7% had plaques with at least 1 high-risk feature. These proportions were 16%, 0.8%, and 2.3%, respectively, among those with CAC = 0. Longitudinal follow-up will shed further light on the prognostic implications of these findings in asymptomatic individuals.

Indexed as

Coronary Artery DiseasePlaque, AtheroscleroticConstriction, PathologicCoronary AngiographyCross-Sectional StudiesFemaleFloridaHumansMaleMiddle AgedObesityOverweightPredictive Value of TestsProtestantismRisk Factorsatherosclerosiscomputed tomographycoronary artery calciumepidemiologysubclinical

Identifiers

PMID36075621
OpenAlexW4280635826

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.